Synthesis fluorescent magnetic nanoparticles in a microchannel using the La Mer process and the characterization of their properties

Nguyen, Thi Hong Hanh; Joen, Hyeong Jin; Kwon, Bong H.; Kim, Hyeong Hoon; Tran, Dai Lam; Mortan, Karl; Go, Jeung Sang

doi:10.1007/s10853-014-8158-7

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…In this system, the precursor is pumped through the inner tube (Qin) to reduce particle adhesion to the wall. Other authors have synthesized MNPs using coaxial flow microdevices (Abou- Hassan et al 2012;Nguyen et al 2014).…”

Section: Continuous Microfluidic Synthesismentioning

confidence: 99%

Synthesis and applications of surface-modified magnetic nanoparticles: progress and future prospects

García-Merino

Bringas

Ortiz

2021

Reviews in Chemical Engineering

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The growing use of magnetic nanoparticles (MNPs) demands cost-effective methods for their synthesis that allow proper control of particle size and size distribution. The unique properties of MNPs include high specific surface area, ease of functionalization, chemical stability and superparamagnetic behavior, with applications in catalysis, data and energy storage, environmental remediation and biomedicine. This review highlights breakthroughs in the use of MNPs since their initial introduction in biomedicine to the latest challenging applications; special attention is paid to the importance of proper coating and functionalization of the particle surface, which dictates the specific properties for each application. Starting from the first report following LaMer’s theory in 1950, this review discusses and analyzes methods of synthesizing MNPs, with an emphasis on functionality and applications. However, several hurdles, such as the design of reactors with suitable geometries, appropriate control of operating conditions and, in particular, reproducibility and scalability, continue to prevent many applications from reaching the market. The most recent strategy, the use of microfluidics to achieve continuous and controlled synthesis of MNPs, is therefore thoroughly analyzed. This review is the first to survey continuous microfluidic coating or functionalization of particles, including challenging properties and applications.

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Section: Continuous Microfluidic Synthesismentioning

confidence: 99%

Synthesis and applications of surface-modified magnetic nanoparticles: progress and future prospects

García-Merino

Bringas

Ortiz

2021

Reviews in Chemical Engineering

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“…In another study performed by Nguyen et al [225] fluorescent magnetic nanoparticles were synthesized in a microchannel using the La Mer process. This method includes wet chemical coprecipitation of ferrous and ferric ions with ammonia where ammonia is mixed with a stirred solution of ferrous and ferric ions.…”

Section: Coaxial Flow Microreactormentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

204

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…The laminated interface is strongly resistant to external disturbance hydrodynamically and the width of the laminated stream is simply controlled by changing the ratio of two inlet flow rates. This flow focusing synthesis in the microchannel can provide a stable and controllable synthesis of nanoparticles such as poly(lactic-co-glycolic acid) (PLGA) nanoparticles, liposomes, and quantum dots [ 28 , 29 ]. However, the direct application of the reported design of the microfluidic methods causes clogging problems in the microchannel with explosive reactions.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Protein Nanoparticles Using NTA End Functionalized Polystyrenes on the Interface of a Multi-Laminated Flow Formed in a Microchannel

et al. 2017

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This paper challenges the production of the protein nanoparticles using the conjugation of Ni2+ complexed nitrilotriacetic acid end-functionalized polystyrene (Ni-NTA-PS) and histidine tagged GFP (His-GFP) hybrid. The microfluidic synthesis of the protein nanoparticle with the advantages of a uniform size, a fast reaction, and a precise control of preparation conditions is examined. The self-assembly occurs on the interfacial surface of the multi-laminated laminar flow stably formed in the microchannel. The clogging of the produced protein nanoparticles on the channel surface is solved by adding a retarding inlet channel. The size and shape of the produced protein nanoparticles are measured by the analysis of transmission electron microscopy (TEM) and scanning electron microscope (SEM) images, and the attachment of the protein is visualized with a green fluorescent image. Future research includes the encapsulation of vaccines and the coating of antigens on the protein surface.

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Synthesis fluorescent magnetic nanoparticles in a microchannel using the La Mer process and the characterization of their properties

Cited by 6 publications

References 35 publications

Synthesis and applications of surface-modified magnetic nanoparticles: progress and future prospects

Synthesis and applications of surface-modified magnetic nanoparticles: progress and future prospects

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Preparation of Protein Nanoparticles Using NTA End Functionalized Polystyrenes on the Interface of a Multi-Laminated Flow Formed in a Microchannel

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