Synthesis for Carbon-14 Labeled dl-Glutamic Acid

Speer, R. J.; Roberts, A. L.; Maloney, M. M.; Mahler, Henry R.

doi:10.1021/ja01129a535

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Cited by 7 publications

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“…hydrolysis Malonic ester reactions have been used extensively to make labeled glutamic acid. For example, glutamic acid-1,2-C214 was prepared as follows (112,175). [This labeled compound has also been made by similar routes (22,175).]…”

Section: Illmentioning

confidence: 99%

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Glutamic Acid: Chemical Syntheses and Resolutions.

Huffman¹,

Skelly²

1963

Chem. Rev.

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Section: Illmentioning

confidence: 99%

“…For example, glutamic acid-1,2-C214 was prepared as follows (112,175). [This labeled compound has also been made by similar routes (22,175).] A synthesis of glutamic acid-2-C14 was developed from labeled acetic acid (166).…”

Section: Illmentioning

confidence: 99%

Glutamic Acid: Chemical Syntheses and Resolutions.

Huffman¹,

Skelly²

1963

Chem. Rev.

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Das Verhalten von isotaktischen Polyacrylsäuren im Organismus. Verteilung und Ausscheidung bei Mäusen

1977

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Isopropyl acrylat~-2,3-'~C and isopropyl acryIat~-2,3-~H were polymerized using anionic initiators. The isotactic polymers were fractionated by fractional precipitation and characterized. The polymer fractions were hydrolysed to polyacrylic acids by trifluoroacetic acid. Aqueous solutions of these radioactive labelled polyacrylic acids were injected intravenously to mice in amounts of 40 to lCOmg/kg. Distribution in organs and the excretion were studied. About two thirds of the dose were excreted within the first two days with a half-life of about 0,s days. Further excretion took place with a half-life of about six weeks. Distribution in the organism was not uniform; the highest concentrations were found in spleen, bones, and liver, i.e. organs being parts of the reticuloendothelial system. A relationship between organ concentration and molecular weight of the polyacrylic acid was only observed in the spleen. Nine weeks after injection about 10% of the dose were still retained in the organism, mainly in the skeleton.

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