Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles

Hao, Rui; Xing, Ruijun; Xu, Zhichuan J.; Hou, Yanglong; Gao, Song; Sun, Shouheng

doi:10.1002/adma.201000260

Cited by 1,318 publications

(787 citation statements)

References 166 publications

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“…), represent a popular class of transition metal oxides and find use in numerous applications such as diagnostic imaging and other biomedical applications [163]. Large particles (~0.5 µm) of the most stable iron oxide, α-Fe2O3 (hematite), have previously demonstrated a large size-dependent effect on reaction with Li + [164], where a structural transformation occurs from the cubic to hexagonal system after insertion of an equivalent of just 0.05 mol.…”

Section: Iron Oxidesmentioning

confidence: 99%

Evaluating the performance of nanostructured materials as lithium-ion battery electrodes

et al. 2013

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Access to the full text of the published version may require a subscription. Rights © Tsinghua University Press and Springer-Verlag Berlin ABSTRACTThe performance of the lithium-ion cell is heavily dependent on the ability of the host electrodes to accommodate and release Li + ions from the local structure. While the choice of electrode materials may define parameters such as cell potential and capacity, the process of intercalation may be physically limited by the rate of solid-state Li + diffusion. Increased diffusion rates in lithium-ion electrodes may be achieved through a reduction in the diffusion path, accomplished by a scaling of the respective electrode dimensions.In addition, some electrodes may undergo large volume changes associated with charging and discharging, the strain of which, may be better accommodated through nanostructuring. Failure of the host to accommodate such volume changes may lead to pulverisation of the local structure and a rapid loss of capacity. In this review article, we seek to highlight a number of significant gains in the development of nanostructured lithium-ion battery architectures (both anode and cathode), as drivers of potential next-generation electrochemical energy storage devices.

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Section: Iron Oxidesmentioning

confidence: 99%

Evaluating the performance of nanostructured materials as lithium-ion battery electrodes

et al. 2013

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“…3,5 Nowadays, MNPs of the iron oxides have become important components in biosensing, magnetic separation, advanced medical screening and therapies, including bio-assays, magnetic resonance imaging (MRI), magnetically guided drug delivery, and hyperthermia, etc. [5][6][7][8][9] Thanks to a variety of excellent properties, magnetite MNPs were also used in many non-biological applications such a Author to whom correspondence should be addressed. Electronic mail: galina@we.lc.ehu.es.…”

Section: Introductionmentioning

confidence: 99%

Iron oxide nanoparticles fabricated by electric explosion of wire: focus on magnetic nanofluids

et al. 2012

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Nanoparticles of iron oxides (MNPs) were prepared using the electric explosion of wire technique (EEW). The main focus was on the fabrication of de-aggregated spherical nanoparticles with a narrow size distribution. According to XRD the major crystalline phase was magnetite with an average diameter of MNPs, depending on the fraction. Further separation of air-dry EEW nanoparticles was performed in aqueous suspensions. In order to provide the stability of magnetite suspension in water, we found the optimum concentration of the electrostatic stabilizer (sodium citrate and optimum pH level) based on zeta-potential measurements. The stable suspensions still contained a substantial fraction of aggregates which were disintegrated by the excessive ultrasound treatment. The separation of the large particles out of the suspension was performed by centrifuging. The structural features, magnetic properties and microwave absorption of MNPs and their aqueous solutions confirm that we were able to obtain an ensemble in which the magnetic contributions come from the spherical MNPs. The particle size distribution in fractionated samples was narrow and they showed a similar behaviour to that expected of the superparamagnetic ensemble. Maximum obtained concentration was as high as 5 % of magnetic material (by weight). Designed assembly of de-aggregated nanoparticles is an example of on-purpose developed magnetic nanofluid

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“…1,2 For example, significant R&D resources have been devoted to nanoparticle technology in diverse fields including electronic and biomedical devices, automotive parts, coatings, drug delivery, gene delivery, catalysis and polymers. [3][4][5][6][7][8][9][10][11][12][13][14] For several of these applications surface functionalization is an important requirement. For example, to change the polarity of the nanoparticles and promote dispersion in organic solvents or polymers chemical treatment by cation exchange or grafting using organosilanes has been extensively practiced.…”

mentioning

confidence: 99%

An improved process for the surface modification of SiO2 nanoparticles

Livi

Giannelis

2012

Green Chem.

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A phosphonium ionic liquid is used as an activator of silanol groups to improve the surface functionalization of silica nanoparticles with fluorosilanes in supercritical CO 2 .Due to their excellent optical, electrical and mechanical properties as well as their unique advantages such as high surface area, nanoparticles can play a key role in many nanotechnology applications. 1,2 For example, significant R&D resources have been devoted to nanoparticle technology in diverse fields including electronic and biomedical devices, automotive parts, coatings, drug delivery, gene delivery, catalysis and polymers. [3][4][5][6][7][8][9][10][11][12][13][14] For several of these applications surface functionalization is an important requirement. For example, to change the polarity of the nanoparticles and promote dispersion in organic solvents or polymers chemical treatment by cation exchange or grafting using organosilanes has been extensively practiced. [15][16][17] In addition, surface functionalization has been used to improve the stability of the nanoparticles and avoid aggregation in various media. 18,19 Surface functionalization is typically carried out in the presence of organic solvents. In some instances and to make the process greener, supercritical CO 2 (scCO 2 ) has been used in place of conventional solvents. However, the grafting density tends to be relatively low. It has been reported that small amounts of a highly basic ionic liquid (<0.5 wt%) can generate silanoates on the surface of silica. We combine here the use of an ionic liquid in scCO 2 to increase the grafting density of fluorosilane on silica. The process results in doubling of the grafting densities with the resulting nanoparticles exhibiting CO 2 -philic behavior. In addition to the increased reactivity and higher grafting density the new process offers the following additional advantages: (i) this is a one-step process, (ii) the use of organic solvents is completely eliminated, (iii) the lengthy steps of purification and drying of the silica are replaced by dilution and filtration, (iv) the ionic liquid can be recovered and reused.We note that our process differs from previous reports using scCO 2 in that low pressures (80 instead of 400 bar) and less amounts of silane (only 10 wt% compared to a 3-10 times molar excess of the corresponding coupling agents used in the literature) are required. 20,21 In addition, previous reports utilizing scCO 2 were limited to dry, fumed silica instead of aqueous dispersions used in our approach. While the primary particles of fumed silica are small and comparable to that of colloidal silica, drying tends to lead to particle agglomeration.While the method can be applicable to different oxides we demonstrate it here using colloidal silica and three different fluorosilanes: (i) perfluorooctyl-methyldimethoxysilane (DMS), (ii) perfluorooctyl-trichlorosilane (TCS), and (iii) perfluorooctyltriethoxysilane (TES). Triphenyloctadecyltriphenylphosphonium iodide (C 18 P I − ) was used as the surface activator. The synthesi...

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Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles

Cited by 1,318 publications

References 166 publications

Evaluating the performance of nanostructured materials as lithium-ion battery electrodes

Evaluating the performance of nanostructured materials as lithium-ion battery electrodes

Iron oxide nanoparticles fabricated by electric explosion of wire: focus on magnetic nanofluids

An improved process for the surface modification of SiO2 nanoparticles

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