Synthesis High Sensivity ZnO Cholesterol Biosensor with One Dimensional Nanostructures

Abstract

Abstract. Chelosterol ZnO biosensors were synthesized by hydrothermal method with predeposited ALD-ZnO seed layers. The ZnO nanostructures were examined by SEM, XRD, AFM, respectively. The XRD is used to analyze the crystal structures of ZnO seed layers that were grown by ALD process, then using SEM and AFM to analysis the surface morphologies of them. Growing of one dimensional ZnO nanostructures on seed layer of 10nm thickness, reveals high sensitivity of 3.15 uA (mg/dl) -1 cm -2 (121.96 uAmM -1 cm -2 ) and low K m value of 0.29mM in 25-100mg/dl cholesterol concentration range. The response time could be as low as 10seconds. In the study, it is found that increasing the aspect ratio of ZnO one dimensional nanostructure also increases the sensitivity and expends the linear measureable range of detecting cholesterol in solution. The thickness of seed layer has a significant influence on sensitivity for one dimensional nano ZnO cholesterol biosensor.

Insights on luminescence quenching of ZnO tetrapods in the detection of hCG

“…A great number of biosensors based on ZnO nanostructures have been developed in the recent years for detection of a wide range of biomedical analytes, such as glucose [3,5,20], cholesterol [8,21], cardiac troponin [22], DNA [23][24][25], among many others [2,4,26].…”