Synthesis, in silico metabolic and toxicity prediction of some novel imidazolinones derivatives as potent anticonvulsant agents

Recent Developments and Biological Activities of 5-Oxo-Imidazolones Derivatives: A Review

“…Among all the compounds tested, maximal protection was reported for compounds with p-OCH3 (IVa), p-OH (IIIa) (36) substitution in phenyl ring on the 4th positions of the imidazolinone ring of series bearing sulfamethoxazole moiety, and p-OCH3 (IVb), o-Cl (Vb) (37). It is important to mention that the majority of the compounds produced significant activity [57].…”

Crystal structure, Hirshfeld surface analysis and interaction energy and DFT studies of 1-(1,3-benzothiazol-2-yl)-3-(2-hydroxyethyl)imidazolidin-2-one

“…These molecules exhibit a wide range of biological applications including as anti-tumor agents (Bé néteau et al, 1999;Ć aleta et al, 2004), antimicrobial agents (Shastry et al, 2003;Latrofa et al, 2005, Singh et al, 2013), analgesics (Kaur et al, 2010, anti-inflammatory agents (Oketani et al, 2001), anti-HIV agents (Nagarajan et al, 2003;Pitta et al, 2013), anti-leishmanial agents (Delmas et al, 2004), anti-cancer agents (Yang et al, 2003;Huang et al, 2006;Kok et al, 2008), anti-hypertensive agents (Saggu et al, 2002), antioxidants, (Ayhan-Kilcigil et al, 2004) and anti-viral agents (Tewari et al, 2006). The imidazolinone moiety is an important scaffold possessing a spectrum of pharmacological actions, which include anti-convulsant, anti-parkinsonism and monoamino-oxidase inhibitory activities (Hari Narayana Moorthy et al, 2012;Desai et al, 2009). Furthermore, imidazolones are anti-bacterial, anti-fungal, anti-viral, anti-cancer and CNSdepressant agents (Naithani et al, 1989;Harfenist et al, 1978).…”