Synthesis of 1-acyl-1H-pyrroles from cyclic 2-(acylmethyl)-1,3-diketones via rearrangement involving transannular interaction

Abstract

Cyclic 2-(acylmethyl)-l,3-diketones are converted into I-acyl-1 H-pyrroles in high yields by ammonium acetate in acetic acid, via rearrangement of a hydroxypyrroline intermediate.