Paal knorr reaction for novel pyrrolo[2,3-d]pyrimidines

Abstract

An expeditious and convenient solid supported synthesis of 1,3,7‐triaryl‐6‐phenyl‐2‐thioxo‐1,2,3,7‐tetrahydropyrrolo [2,3‐d]pyrimidin‐4‐one derivatives from readily accessible N,N‐disubstituted thiobarbituric acids under microwaves utilising Paal Knorr reaction is described.

Review on synthesis of pyrrole derivatives promoted by nanoparticles

“…This method consists of reaction of γ-diketone and primary amines. From acidic catalysts that used for the synthesis of N-substituted pyrroles can be mentioned to the zeolite, [27] Ti (O-i-Pr) 4, [28] p-TSA, [29] Al 2 O 3, [30] SnCl 2 .2H 2 O, [31] Sc (OTf) 3, [32] RuCl 3, [33] InCl 3, [34] layered zirconium phosphate and sulfophenyl phosphonate. [35] There are some reported procedures for the synthesis of polysubstituted pyrroles in the presence of FeCl 3, [36] AgOAc, [37] TiCl 4 /Zn, [38] I 2 /ZnCl 2, [39] and Sm (O i Pr) 3 [40] catalysts.…”

<strong>An expedient synthesis of some new Pyrazole, Pyrazolone, Hydrazone and Thiosemicarbazide.</strong>

“…Various literature reported that, both synthetic as well as natural nitrogen containing heterocyclic molecules possesses a significant pharmaceutical importance, a large number have been made up to clinics for health care worldwide. Pyrazole and pyrazolone are classes of heterocycles which exhibits diverse chemical and biological properties [2][3][4][5][6][7][8][9][10][11][12][13][14][15] .…”