Synthesis of 1-aryl-2,4,10a-Triazaphenanthrene-3-Selones Via a Three-Component Condensation of Isoquinolin-1-Amine, Potassium Selenocyanate and an Acyl Chloride

Abstract

A simple, one-pot synthesis of six 1-aryl-2,4,10a-triazaphenanthrene-3-selones has been achieved with moderate to good yields via a three-component condensation of isoquinolin-1-amine, potassium selenocyanate and variously substituted benzoyl chlorides in acetone at room temperature.

Synthesis of 2-Selanylidene-1,9A-Dihydro-2H-Pyrido[1,2-A]Pyrimidine Derivatives

“…The structures of compounds 4a-f were deduced from their elemental analyses and their IR, 1 H NMR and 13 C NMR spectra. The mass spectra of these compounds displayed molecular ion peaks at appropriate m/z values.…”

“…IR spectra were recorded on a Shimadzu IR-470 spectrometer. NMR spectra were obtained on a Brucker DRX 500 Avance spectrometer ( 1 H NMR at 500 Hz, 13 C NMR at 125 Hz) in DMSO-d 6 using TMS as an internal standard. Chemical shifts (δ) are given in ppm.…”

“…11 Recently, a few syntheses of heterocycles from acyl isoselenocyanates have been reported. 12,13 As a part of our current studies on the development of new routes in organic synthesis, [14][15][16] we report here the results of our study on the reaction between aryl isoselenocyanates and acetylenic esters in the presence of pyridines.…”