Synthesis of 2,4,6-triisopropylbenzenesulfonic acid N-azolides and their regulatory effect on cell proliferation, energy expenditure, and apoptosis processes

Abstract

A series of new N-azolides of 2,4,6-triisopropylbenzenesulfonic acid have been synthesized. Their biological activity with respect to the processes of cell proliferation, energy expenditure, and programmed cell death (apoptosis) has been studied. Convincing evidence is obtained for pronounced immunomodulating and cytoprotecting properties of two compounds (N-imidazolide and N-triazolide of 2,4,6-triiospropylbenzenesulfonic acid), which produce a positive influence directed at pathological states, in particular, cell proliferation, cell energy expenditure, and apoptosis.

Reactivity of 1,2,3-triazoles towards sulfonyl chlorides. A novel approach to 1- and 2-sulfonyl-4-azolyl-1,2,3-triazoles

“…Though this reaction is recognized as a traditional method to prepare 1-sulfonyl triazoles 14 the publications with data on reactivity of 1,2,3-triazoles with sulfonyl chlorides are innumerous. 22,23,[24][25][26][27][28][29][30] The parent 1,2,3-triazole, 4-phenyl-and 4-ethoxycarbonyl-1,2,3-triazole are shown to react with tosyl chloride under basic conditions to form mainly 1-tosyl-1,2,3-triazoles with a small impurity of 2-substituted triazoles. [22][23][24] Conversely, 4-nitro-1,2,3-triazole reacts with 2,4,6-trimethylbenzene-1-sulfonyl chloride to give a mixture of 1-substituted-and 2-substituted-1,2,3-triazoles in almost equal quantity.…”