Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles

Abstract

Abstract:A procedure has been developed for synthesis of 2-alkenyl-2H-indazoles starting from 2-(2-carbonylmethyl)-2H-indazoles, which are prepared by gallium/aluminium-and aluminium-mediated, direct, regioselective alkylation of indazoles with α-bromocarbonyl compounds. The structure of 3-(2H-indazol-2-yl)-2H-chromen-2-one was proven by X-ray crystallography. The styrene-and coumarin-2H-indazoles produced by using the new method were found to have interesting fluorescence properties.

Fluoromethoxymethylation of Nitrogen Heterocyclic Compounds with Fluoromethyl Iodide

“…As an important member of heteroarenes, the 1 H -indazole ring system, which displays a broad range of interesting biological properties, is used in innumerable agrochemicals and pharmaceuticals . Therefore, we turned our attention to the scope of 1 H -indazoles under optimized conditions.…”