Synthesis of 3-(Alkyl and Aryl)thio-2-isocephems

A Highly Efficient Procedure for 3-Sulfenylation of Indole-2-carboxylates

“…These harsh chlorinations are also incompatible with certain functionalities. The formation of sulfenyl chlorides using N -chlorosuccinimide has been reported . This milder method of chlorination expanded the scope of functional group compatibility enabling the formation of thermally unstable aliphatic sulfenyl chlorides, including those with ester groups .…”