Synthesis of 3‐substituted‐4‐methyl‐5‐acetyl‐4‐thiazoline‐2‐thione

Abstract

The reaction of various potassium salts [RNHC( =S)SK, R = N(CH,),, morpholino, piperidino, and hexahydro-l-(lfQazepinyl] with 3-chloro-2,4-pentanedione in ethanol at 25-30° afforded the 1-acetylacetonyl substitutedaminodithiocarbamates 1-4 [RNHC( =S)SCH(COCH,)J. Under refluxing conditions, the same reactants gave the heterocyclic compounds 5-8. Possible mechanism and supporting ir, nmr and mass spectral data are discussed.