Synthesis of 4-Aryl-5-nitro-1,2,3-triazoles

(E)-N-(4-{[1-(Prop-2-en-1-yl)-1H-1,2,3-triazol-4-yl]methoxy}benzylidene)morpholin-4-amine

“…For the biological activity of triazole derivatives, see: Bringmann et al (2004); Nelson et al (2004); Nithinchandra et al (2013); Sherement et al (2004); Singh et al (2012). For similar structures, see: Akkurt et al (2013a,b).…”

“…1,2,3-Triazoles are attractive constructs, because of their unique chemical properties and they find many applications in organic and medicinal chemistry (Nithinchandra et al, 2013). They are found to be potent antimicrobial and antiviral agents (Sherement et al, 2004). The morpholine moiety has been utilized extensively by the pharmaceutical industry in drug design, often because of the improvement in pharmacokinetic properties it can confer.…”

Another Way to the Synthesis of 1,2,3‐Triazoles

“…1,2,3‐Triazoles have a broad range of biological activity, and there are numerous examples in the literature including antibacterial activity [1, 2], antiviral activity [3], anti‐convulsant [4], selective β3‐adrenergic receptor agonism [5], and so on. A few methods for the preparation of 1,2,3‐triazole derivatives have been developed.…”

4-{[5-Methyl-2-(propan-2-yl)phenoxy]methyl}-1-(4-nitrobenzyl)-1H-1,2,3-triazole

“…Indeed, heterocyclic compounds containing this motif exhibit anticancer activity (Sté phan et al, 1995), and are known to be antineoplastic (Passannanti et al,1998), antimicrobial (Sheremet et al, 2004) and anti-HIV agents (Velá zquez et al, 1998). In this work we have synthesized 4-{[5-Methyl-2-(propan-2-yl)phenoxy]methyl}-1-(4-nitrobenzyl)-1H-1,2,3-triazole by a 1,3-dipolar cycloaddition reaction of 4-nitrobenzoyl azide with 1-isopropyl-4-methyl-2-(prop-2-yn-1-yloxy)benzene and report its structure here.…”