Synthesis of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine derivatives as potent antimicrobial agent

Abstract

A series of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine (7-12) have been synthesised by reduction of 3-alkyl-2,6-diarylpiperidin-4-one using the Grignard reagent. Structural assignments and conformational analysis of the compounds were established based on the spectral studies. All the piperdin-4-ol derivatives (7-12) were assayed for antibacterial, antifungal and anthelmintic activities and they exhibited significant results.

Synthesis and antimicrobial activity of some 2- Piperidinomethylamino-4-(7-H/substituted coumarin-3-yl)- 6-chlorosubstitutedphenyl pyrimidines

“…The piperidine nucleus is also an important moiety in medicinal chemistry research [16]. A number of piperidine ring containing chemical compounds have also been reported as antimicrobial agents [17][18][19][20].…”

Stereochemical effect on biological activities of new series of piperidin-4-one derivatives

“…The parent compounds, cis-2,6-diarylpiperidin-4-one (1 -5) were synthesised by Mannich reaction (Noller & Baliah 1948;Maruthavanan & Venkatesan 2013). The reduction of parent q 2015 Taylor & Francis *Corresponding author.…”

“…The compound containing piperidine scaffold acts as pharmaceutical agents like antihypertensive, antibacterial, antimalarial, anticonvulsant, antifungal, antituberculosis, antipyretic and antiinflammatory agents (Pulgar & Harp 2014). In the present investigation, a new series of piperidin-4-one derivatives were synthesised in continuation of our earlier work (Maruthavanan & Venkatesan 2013) in order to find out their stereochemical effect on in vitro antibacterial, in vitro antifungal and in vitro anthelmintic activities.…”

Spectral and Structural Perspectives of 1,3,3-Trimethyl-2,6-diphenylpiperidin-4-one

“…Similarly, piperidin-4-one derivatives are considered as a ubiquitous structural unit as it possesses both nucleophilic (NH) and electrophilic (-CO-) centres which could be modified and aid in building or expanding the structures conveniently. This is evidenced by the availability of literature reports [5][6][7][8][9][10] about the biologically active compounds of the piperidin-4-one.…”