Synthesis of 4-thio-5-(2′′-thienyl)uridine and cytotoxicity activity against colon cancer cells in vitro

Abstract

Antiproliferative effect of 4-thio-5-(2′′-thienyl)uridine on MC-38 cells, HT-29 cells and normal human fibroblasts cells.

A Visible‐Light‐Promoted C‐H Arylation and Heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions

“…Its modification by chemical means to expand its functional scope is a hotspot of current research (Le, Koo, Joo, & Seo, 2017). Among them, 5‐aryl (hetero) uridine is often used as a potential drug due to its unique pharmacological and biological activities, and is an important raw material for the preparation of antiviral (Idzik, Cywinski, Cranfield, Mohr, & Beckert, 2011; Kim, & Hong, 2016), antitumor (Meščić et al., 2015), anticancer (Kim et al., 2018; Zhang, Li, Qin, Xu, & Ma, 2016), and anti‐inflammatory drugs (Jiang et al., 2016). In addition, the modified uridine can form a stable Watson‐Crick base pair with natural nucleosides (Fagnani, Bou Zerdan, & Castellano, 2018; Mohan et al., 2020), and the presence of aryl groups can prolong the conjugation (Manna, Sarkar, & Srivatsan, 2018; Kapdi et al., 2020) and enhance the molecule's fluorescence properties.…”