Synthesis of 5‐(6‐Pyridazinone‐3‐yl)‐2‐Glycosylamino‐1,3,4‐Oxadiazoles

Abstract

-5g were prepared by the reaction of glycosyl isothiocyanates with the compounds 1,4,5,6-tetrahydro-3-hydrozinecarbonyl-6-pyridazinone (1) and 1,6-dihydro-3-hydrozinecarbonyl-6-pyridazinone (2). The terminal heterocyclic compounds 1,3,4-oxadiazole derivatives were obtained from cyclization of compounds (3a-3g) and (5a-5g) by mercuric acetate. Their structures were confirmed by IR, 1 H NMR, MS and elemental analyses.

Pharmacological activities of pyridazines and pyridazinone Derivatives: A Review on biologically active scaffold

“…MCI-154, 6-[4-(4'pyridylamino)phenyl]-4,5-dihydro-3(2H)-pyridazinone hydrochloride trihydrate, is a calcium sensitizer that has more potent positive inotropic effect than that of pimobendan, adibendan and sulmazole [38,39]. Over the past few years, a number of pyridazine derivatives have been applied to antiarrhythmics and antianginals [40]. Effects of Cardiotonic Drugs Ca 2+ sensitizers, exert positive inotropic effects without increasing intracellular Ca 2+ transient.…”

“…Atnitubercular activity Some pyridazinone and phthalazinone derivatives (39,40) carrying N-(phenylsulfonyl) acetohydrazide moiety at position 2 of these rings were exhibited antitubercular activity against M. tuberculosis H37 Rv. Unsubstituted compounds were more active than after the substitution of chlorine at the para position in the phenyl ring [79].…”

“…Norflurazone, 4-chloro-5-(mthylamino)-2-(alfa,alfa,aalfa-trifloro-m-tolyl)-3-(2H)-pyridazinone and fluorinated phenol pyridazinone was used as herbicide. The HCV NS5B polymerase inhibitors derived from 4-(10,10-dioxo-10,40dihydro-10k6-benzo [10,20,40]thiadiazin-30-yl)-5-hydroxy-2H-pyridazin-3-ones [105].…”