Synthesis of 5-enamine-4-thiazolidinone derivatives with trypanocidal and anticancer activity

Features of antimicrobial activity of some 5-aminomethylene-2-thioxo-4-thiazolidinones

“…Chemistry. Synthetic procedure and physicalchemical properties of compounds 1-13 have been described earlier [19].…”

“…Also, in some structure -activity relationship studies (SAR analysis) it had been shown that incorporation of aromatic amino acids into organic compounds significantly improves the potency and selectivity of antibacterial activity [14]. As part of our research in the field of biologically active heterocycles [15][16][17][18], herein we report the antimicrobial properties of new 5-enamine-4-thiazolidones with L-βphenyl-α-alanine fragment in molecules [19]. Noteworthy, we have previously established an interesting antitumor and antitrypanosomal activity of this class of compounds.…”

The influence of the polymerization approach on the catalytic performance of novel porous poly (ionic liquid)s for green synthesis of pharmaceutical spiro-4-thiazolidinones

“…[1][2][3][4][5][6] In addition, 4-thiazolidinone derivatives are privileged heterocyclic compounds with signicant potential pharmaceutical performance, especially in the design of various anticancer agents. [7][8][9] Therefore, several methods have been investigated for the synthesis of spiro [indole-thiazolidinones] compounds by reacting isatins with mercaptoacetic acid and amines under various conditions. [10][11][12][13] However, many reported methods suffer from drawbacks, such as longer reaction times, high reaction temperature, use of ammable solvents, tedious workup, lower yields of the products, and expensive catalysts.…”

Synthesis antimicrobial and antitumor activities of 2-[5-(2-R-benzyl)thiazol-2-ylimino]thiazolidin-4-ones

“…These derivatives have also been used as sensitive analytical reagents. 4-Thiazolidone motif is considered as privileged scaffolds in medicinal chemistry and is currently the subject of extensive research [2][3][4][5][6][7][8][9][10][11][12].…”