Synthesis of 6-substituted 7-aryl-5,6-dihydropyrido[2,3-d]pyrimidine(1H,3H)-2,4-diones using the Vilsmeier reaction

Girreser, Ulrich; Heber, Dieter; Schütt, Martin

doi:10.1016/j.tet.2004.09.075

Cited by 29 publications

(10 citation statements)

References 7 publications

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“…substituted pyrido[2,3-d]pyrimidines were obtained [50]. In the pharmacological evaluation of this group of compounds, derivative 28 possessing naphthyl group at 5-position (Fig.…”

Section: Non-fused Ringsmentioning

confidence: 99%

Potent Adenosine A1 and A2A Receptors Antagonists: Recent Developments

Yuzlenko

Kieć‐Kononowicz

2006

CMC

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This review summarizes the current tendencies observed in the past 5 years in the development of A(1) and A(2A) adenosine receptor antagonists performed in various academia and industry. A(1) and A(2A) AR antagonists are as well xanthines as heteroaromatic derivatives and are most commonly 6:5 fused heteroatomic compounds. Among xanthine-based compounds, some common features could be pointed out. The recent A(1) AR ligands which show good biological profile, possess long alkyl chains in position 1 and 3 as well as bulky C(8)-substituent, while A(2A) AR antagonists with a high A(2A) AR affinity are C(8)-styryl substituted with N(1)-alkyl/alkynyl moiety or fused tricyclic xanthines possessing heteroatom(s) in the third cycle. The research in the field of heteroaromatic A(1) and A(2A) ARs antagonists impressively has a wide range. Ligands are as well non-fused monocyclic substituted compounds as fused bi- and tricyclic derivatives with the nitrogen, oxygen and sulfur heteroatoms. Most often, adenosine A(1) receptor non-xanthine antagonists are adenine-based, having substituted amino group and variable nitrogen atoms positions in the molecules. A(2A) AR ligands show good affinity when furanyl function, which is crucial for binding, is present in the fused bicyclic and tricyclic analogs. Moreover, tricyclic nitrogen containing antagonists in order to be active, frequently possess long-alkylphenyl moiety.

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“…substituted pyrido[2,3-d]pyrimidines were obtained [50]. In the pharmacological evaluation of this group of compounds, derivative 28 possessing naphthyl group at 5-position (Fig.…”

Section: Non-fused Ringsmentioning

confidence: 99%

Potent Adenosine A1 and A2A Receptors Antagonists: Recent Developments

Yuzlenko

Kieć‐Kononowicz

2006

CMC

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“…Ketonic Mannich bases are β‐bifunctional reactive synthons. These compounds have been widely used as good alkylating agents [27]. C‐alkylation reaction of ketonic Mannich bases w\ith active hydrogen derivatives has been reported [28].…”

Section: Resultsmentioning

confidence: 99%

A Versatile Synthesis, PM3‐Semiempirical, Antibacterial, and Antitumor Evaluation of Some Bioactive Pyrazoles

Hamama

El-Gohary

Soliman

et al. 2012

Journal of Heterocyclic Chem

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“…Biological activities of compounds containing uracil moiety incorporated other heterocycles have been reported . Considering these reports, the development of new and simple synthetic method for the efficient preparation of heterocycles containing uracil ring fragment is therefore an interesting challenge.…”

Section: Introductionmentioning

confidence: 99%