Synthesis of a bis-Phosphonic Acid Derivative of Trolox, a New Potential Antioxidant

Bekker, K. S.; Чуканов, Н. В.; Григорьев, И. А.

doi:10.1007/s10600-013-0746-2

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Direct Acylation Of Tetraethyl Aminobisphosphonates1

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“…Acylation of pamidronic acid ester 22 by using HBTU (2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate) was used to prepare a catecholic derivative, which was then bound to the surface of magnetic iron oxide nanoparticles (Scheme 31) [144]. The particle 63 has been designed to remove uranyl ions from blood.…”

Section: Direct Acylation Of Tetraethyl Aminobisphosphonatesmentioning

confidence: 99%

Synthetic Procedures Leading towards Aminobisphosphonates

Chmielewska

Kafarski

2016

Molecules

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Abstract:Growing interest in the biological activity of aminobisphosphonates has stimulated the development of methods for their synthesis. Although several general procedures were previously elaborated to reach this goal, aminobisphosphonate chemistry is still developing quite substantially. Thus, innovative modifications of the existing commonly used reactions, as well as development of new procedures, are presented in this review, concentrating on recent achievements. Additionally, selected examples of aminobisphosphonate derivatization illustrate their usefulness for obtaining new diagnostic and therapeutic agents.

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Section: Direct Acylation Of Tetraethyl Aminobisphosphonatesmentioning

confidence: 99%