Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects on endothelial cell growth

Effect of covalent antithrombin-heparin complex on developmental mechanisms in the lung

“…This finding complements data in our study where both L-AT and heparin also displayed antiangiogenic effects with decreased growth in vascular area and less complex branching compared with L-ATH. Heparin has been shown to significantly effect cell proliferation (27,66) and chemotaxis (74), which may have been a factor in the uneven branching and dilation observed in heparin-treated lungs (Fig. 1).…”

Synthesis of Some Novel D‐Glucuronic Acid Acetylated Derivatives as Potential Anti‐Tumor Agents

“…Glucuronates derivatives were reported to readily undergo bcis-elimination to give the corresponding 4,5-unsaturated species by treatment with a base [26][27][28][29][30][31][32]. The electron-withdrawing effect of the carbonyl group makes the a-proton (H-5) sufficiently acidic to be removed by a base.…”

Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei

“…This is considered a step in cancer therapy, where the study of angiogenesis inhibitors is of great importance [3]. Inflammation also exposes the body to prolonged levels of ROS, causing an accumulation of oxidative damage in tissues.…”