Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei

Castro, Allisson Jhonatan Gomes; Castro, Luiza Sheyla Evenni P. Will; Santos, Marilia S. Nascimento; Faustino, Monique G.C.; Pinheiro, Thuane S.; Dore, Celina Maria Pinto Guerra; Baseia, Iuri Goulart; Leite, Edda Lisboa

doi:10.1016/j.bionut.2013.08.004

Cited by 20 publications

(12 citation statements)

References 32 publications

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“…5b, the scavenging rate of EPS-2 was 14.86 and 86.90 % higher than that of EPS and EPS-1 at a dosage of 1,000 mg/L, respectively. The scavenging rate of EPS-2 was also much higher than 35 % of Caripia montagnei (Castro et al 2014) and 68 % of Agaricus blazei . The IC 50 value of EPS-2 (465 mg/L) was lower than 5,230 mg/L of A. bisporus and 719 mg/L of Phellinus nigricans (Wang et al 2014a).…”

Section: Evaluation Of Antioxidant Activities In Vitromentioning

confidence: 81%

Purification, characterization, antioxidant activity and anti-aging of exopolysaccharides by Flammulina velutipes SF-06

Cui

Gao²,

Zhang

et al. 2014

Antonie van Leeuwenhoek

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The main objective of this work was to purify the exopolysaccharides (EPS) of Flammulina velutipes SF-06 and investigate the relationship between the different purified fractions and bioactive activity. Two fractions (EPS-1 and EPS-2) were separated and purified by DEAE-52 cellulose and Sephadex G-100 cellulose column chromatography. Monosaccharides composition analysis by gas chromatography indicated that EPS, EPS-1 and EPS-2 were heteropolysaccharides in which rhamnose was a major component. Fourier transform infrared (FT-IR) analysis detected furanose-ring in EPS-1 and EPS-2. All fractions possessed considerable antioxidant activity, while EPS-2 has stronger antioxidant activity than EPS and EPS-1 in vitro. The EPS also exhibited potent anti-aging activation in mice, such as increased catalase and total antioxidant capacity, and decreasing the malondialdehyde (MDA) content. Both the antioxidant in vitro and anti-aging in vivo potentials of EPS could be further utilized in the food industry.

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Section: Evaluation Of Antioxidant Activities In Vitromentioning

confidence: 81%

Purification, characterization, antioxidant activity and anti-aging of exopolysaccharides by Flammulina velutipes SF-06

Cui

Gao²,

Zhang

et al. 2014

Antonie van Leeuwenhoek

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“…Our results showed that all concentrations of WSP treatment, 200 and 400 μg/mL of DASP and CASP treatment significantly inhibited the overproduction of NO caused by LPS (Figure ). Many other types of polysaccharides, such as polysaccharides extracted from fungi Caripia montagnei and Lentinus edodes , could also inhibit excessive NO production stimulated by LPS (Castro, Castro, Santos, & Leite, ; Xu, Yasuda, Nakamura‐Tsuruta, Mizuno, & Ashida, ). iNOS is the main enzyme catalyzing the formation of NO in LPS treated macrophages, and iNOS gene transcription is mainly modulated by the transcription factor NF‐κB (Connelly, Jacobs, Palacioscallender, Moncada, & Hobbs, ).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory effects of polysaccharides from purple sweet potato on lipopolysaccharide treated RAW 264.7 macrophages

et al. 2018

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Immunomodulatory effects of water-soluble polysaccharide (WSP), dilute alkali-soluble polysaccharide (DASP), and concentrated alkali-soluble polysaccharide (CASP) from purple sweet potato were evaluated by using lipopolysaccharide (LPS) treated RAW264.7 macrophage cell models. Results showed WSP, DASP, and CASP (100, 200, and 400 lg/mL) could suppress abnormal phagocytosis, overproduction of TNF-a and IL-6, and abnormal apoptosis caused by LPS. The high doses (200 and 400 lg/mL) of DASP and CASP could distinctly reduce excessive NO production as compared with LPS treatment group. In addition, 400 lg/mL of WSP, DASP, and CASP treatment groups exhibited dramatic decrease in the overexpression of IL-1b stimulated by LPS. Moreover, 200 and 400 lg/mL of WSP, DASP, and CASP markedly improved anti-inflammatory cytokine IL-10 as compared with LPS treatment group. Furthermore, 400 lg/mL of WSP and DASP treatments significantly increased the level of IL-10 in nonstimulated macrophages when compared with normal control group. Practical applicationsPurple sweet potato [Ipomoea batatas (L.) Lam] is one type of highly nutritional vegetable containing many vitamins, minerals, dietary fiber, anthocyanin, and polysaccharides. In addition, it is also one of health-promoting edible plant sources. Recently, polysaccharides have attracted extensive attentions due to their various biological activities. Our study reveals that polysaccharides extracted from purple sweet potato are effective in protecting macrophages damaged by lipopolysaccharide. Therefore, polysaccharides from purple sweet potato have anti-inflammatory efficacy.Thus, this study indicates the potential applications of purple sweet potato polysaccharides in functional food.

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“…polysaccharides (Dore, et al, 2007;Lu, et al, 2008;Lavi, Levinson, Peri, Hadar, & Schwartz, 2010;Adebayo, Oloke, Majolagbe, Ajani, & Bora, 2012;Ruthes, et al, 2013aRuthes, et al, , 2013bRuthes, et al, , 2013cChang, Lur, Lu, & Cheng, 2013;Castro et al, 2014;Silveira et al, 2014;Silveira et al, 2015), terpenes (Kamo, Asanoma, Shibata, & Hirota, 2003;Yoshikawa et al, 2005;Dudhgaonkar, Thyagarajan, & Sliva, 2009;Ma, Chen, Dong, & Lu, 2013;Tung et al, 2013;Xu, Yan, Bi, Han, Chen, & Wu, 2013;Choi, et al, 2014a), phenolic compounds (Quang, Harinantenaina, Nishizawa, Hashimoto, Kohchi, Soma, & Asakawa, 2006a;Quang et al, 2006bKohno et al, 2008Stanikunaite, Khan, Trappe, & Ross, 2009;Hsieh et al, 2010;Lee, & Huang et al, 2011b;Chen et al, 2013;Taofiq et al, 2015), sterols (Huang, et al, 2010;Ma, Chen, Dong, & Lu, 2013 anti-inflammatory activity of extracts prepared from mushrooms after undergoing some food processing procedures. The results showed reduced activity compared to fresh samples, which implies that anti-inflammatory compounds present in these mushrooms were degraded, e.g due to suseptibility to heating.…”

Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

“…fruiting bodies or mycelia and tested for anti-inflammatory activity either in vivo (Lu et al, 2008;Ruthes et al, 2013c;Silveira et al, 2015), following a typical model similar to human acute inflammation, or in vitro for inhibition of cytokine or NO production (Dore et al, 2007;Chang et al, 2013;Castro et al, 2014).…”

Section: Polysaccharidesmentioning

confidence: 99%

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

108

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei

Cited by 20 publications

References 32 publications

Purification, characterization, antioxidant activity and anti-aging of exopolysaccharides by Flammulina velutipes SF-06

Purification, characterization, antioxidant activity and anti-aging of exopolysaccharides by Flammulina velutipes SF-06

Immunomodulatory effects of polysaccharides from purple sweet potato on lipopolysaccharide treated RAW 264.7 macrophages

Anti-inflammatory potential of mushroom extracts and isolated metabolites

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