1981
DOI: 10.1016/0014-5793(81)80394-8
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Synthesis of a new neuropeptide, the head activator from hydra

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1981
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Cited by 17 publications
(5 citation statements)
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“…Identical peptides have since been purified from higher‐organism tissues such as human and bovine hypothalamus, and rat intestine (Bodenmuller and Schaller 1981). Early studies revealed that the purified peptide was active only at very low concentrations, a result that was later supported by analysis of chemically synthesized HA (Birr et al 1981; Schaller and Bodenmuller 1981). Subsequent experiments by molecular sieve chromatography suggested that the peptide forms homodimers with high affinity (K d ≈ 1 nM; Bodenmuller et al 1986), which led to the hypothesis that inactivation at higher concentrations is due to self‐association.…”
mentioning
confidence: 89%
“…Identical peptides have since been purified from higher‐organism tissues such as human and bovine hypothalamus, and rat intestine (Bodenmuller and Schaller 1981). Early studies revealed that the purified peptide was active only at very low concentrations, a result that was later supported by analysis of chemically synthesized HA (Birr et al 1981; Schaller and Bodenmuller 1981). Subsequent experiments by molecular sieve chromatography suggested that the peptide forms homodimers with high affinity (K d ≈ 1 nM; Bodenmuller et al 1986), which led to the hypothesis that inactivation at higher concentrations is due to self‐association.…”
mentioning
confidence: 89%
“…Later a molecule of identical structure was isolated from rat intestine and human hypothalamus. A peptide of that sequence was synthesized and shown to be biologically active (Birr et al, 1981). A peptide of that sequence was synthesized and shown to be biologically active (Birr et al, 1981).…”
Section: Introductionmentioning
confidence: 99%
“…The sequence was determined to be pGlu-Pro-Pro-Gly-Gly-Ser-Lys-Val-Ile-Leu-Phe Schaller and Bodenmiiller, 1981). A peptide of that sequence was synthesized and shown to be biologically active (Birr et al, 1981). The synthetic HA, like the purified HA from biological sources, was found to be unreliable in biological experiments.…”
Section: Introductionmentioning
confidence: 99%
“…Whether this has any functional implication remains to be elucidated. Meanwhile, we have confirmed the structure of the head activator by chemical synthesis (16) and could show that the synthetic product is chemically and biologically indistinguishable from the native head activator from hydra.…”
mentioning
confidence: 57%