Synthesis of a novel thermo/pH sensitive nanogel based on salep modified graphene oxide for drug release

Bardajee, Ghasem Rezanejade; Hooshyar, Zari; Farsi, Maryam; Mobini, Akram; Sang, Golnaz

doi:10.1016/j.msec.2016.11.109

Cited by 56 publications

(32 citation statements)

References 39 publications

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“…Other vital peaks at 1221 and 1050 cm -1 were represented the functional group of epoxy (C-O) and alkoxy group (C-O), respectively. These oxygenated functional groups indeed confirmed the graphite had oxidized into GO which consistent with the literature [16][17].…”

Section: Pxrd Analysissupporting

confidence: 89%

“…In the GO spectrum, O-H stretching vibrations peak was found at 3362 cm -1 that corresponds to the carboxyl and hydroxyl groups and residual water in interlayers of GO. These functional groups enable GO to have better dispersibility in water [16]. Besides that, C=C bonds were detected at 1626 cm -1 indicating the main structure of graphite remained and unoxidized.…”

Section: Pxrd Analysismentioning

confidence: 97%

“…This extent of expansion may be due to several factors such as the anionic size of herbicide, charge, orientation, and interaction between graphite oxide and herbicide [1]. Theoretically, the intercalation of MCPA with graphite oxide involved non-covalent dynamic bonding interactions such as hydrogen bonding, π-π stacking, and electrostatic forces bounding to each other due to the presence of oxygen groups as the reactive sites [16].…”

Section: Pxrd Analysismentioning

confidence: 99%

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Physicochemical Characterization and Controlled Release Formulation on Intercalated 2-Methyl-4-chlorophenoxy Acetic Acid-Graphite Oxide (MCPA-GO) Nanocomposite

et al. 2020

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In this present work, herbicide named 2-methyl-4-chlorophenoxy acetic acid (MCPA) was intercalated into the graphite oxide through ion-exchange method to produce an MCPA-GO nanocomposite as an herbicide delivery system. The formation of MCPA-GO nanocomposite was confirmed by using PXRD, Fourier Transform Infrared Spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), UV-Visible Spectroscopy and Accelerated Surface Area Surface (ASAP). As for PXRD pattern, there was increasing in the basal spacing of the nanocomposite from the graphite oxide which by 9.3 to 9.7 Å indicated that MCPA has successfully inserted into the interlayers of the graphite oxide. Meanwhile, the FTIR spectrum showed the appearance of a new peak in MCPA-GO nanocomposite at 1308 cm -1 represents the functional group of carboxylate (COO -). This peak is very necessary for the confirmation of the anionic form of MCPA inserted into the interlayers of graphite oxide. The controlled release property was also done for further investigation by using various aqueous media to determine the percentage release of MCPA from the nanocomposite. The percentage of herbicide release in Na3PO3 solution was higher than in Na2CO3 and NaCl solution proved that the release properties exhibit the potential application of graphite oxide as effective nanocarrier of herbicides. MCPA-GO nanocomposite suggested being most promising herbicide since it can lower the toxicity of precursor MCPA, high biocompatibility, and more efficient in herbicide delivery system.

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Section: Pxrd Analysissupporting

confidence: 89%

Section: Pxrd Analysismentioning

confidence: 97%

Section: Pxrd Analysismentioning

confidence: 99%

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Physicochemical Characterization and Controlled Release Formulation on Intercalated 2-Methyl-4-chlorophenoxy Acetic Acid-Graphite Oxide (MCPA-GO) Nanocomposite

et al. 2020

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“…In vitro drug release studies showed that the nanogels exhibited sustained and faster release of doxorubicin in acidic conditions (pH=5.0) and high temperature (42 ˚C) compared with physiologic conditions. Cytotoxicity studies in HeLa cells revealed that doxorubicin loaded nanogels showed superior cytotoxicity compared with free doxorubicin [77]. Zhou et al, synthesized a novel crosslinker containing three vinyl groups and copolymerized with NIPAM to prepare novel nanogel sensitive to pH and temperature.…”

Section: Microgelsmentioning

confidence: 99%

A Review on pH and Temperature Responsive Gels in Drug Delivery

2020

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Anticancer drugs play important roles in cancer treatment. However, these drugs have many disadvantages such as poor solubility, high toxicity, and serious side effects like hair loss, nausea and vomiting, anemia etc. To overcome these drawbacks, many attempts have been made to develop novel controlled drug delivery systems. They can encapsulate the drug and release it to the cancer site without leaking into other sites. The employment of multi-responsive hydrogels as a drug delivery system have some advantages over other drug delivery systems due to their ease of preparation, high efficiency, high-water content, tunable physical, and biological properties. The most advantages of these hydrogels is the volume phase transitions in their crosslinked three-dimensional networks as exposure to external stimuli such as temperature, pH, pressure, electric field, magnetic field and light. There has been research on other drug delivery systems which can respond to changes in pH and temperature for targeted drug release. Among those, gels have been studied mostly for their dual responsiveness. This provides an update on progress of gel based dual pH and temperature responsive drug delivery systems. Various systems under these categories for targeted and controlled delivery of different classes of drugs such as ant diabetic and antibiotic drugs with special emphasis on anticancer drugs are discussed in this review. Abstract: Biography:Ghasem Rezanejade Bardajee: He Received his Ph.D. degree in Chemistry from Sharif University of Technology. He is currently a professor at the faculty of chemistry of the Payame Noor University (Iran). His research encompasses the sensitive nanocomposite hydrogels, green chemistry, drug delivery, quantum dots, and solar cells.

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“…They are three-dimensional, water soluble, cross-linked hydrogel materials in the nanoscale size range with a high loading capacity for guest molecules and act as drug carrier systems [101]. Nanogels are the novel drug delivery systems for both hydrophilic and hydrophobic drugs [102].…”

Section: Nanogelsmentioning

confidence: 99%

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2020

ANN

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Emergence of various nanoscale drug carrier platforms as Drug Delivery Systems (DDS) has revolutionized the field of medicine. Nonetheless, the side-effects due to non-specific distribution of anticancer therapeutics in normal, healthy tissues remains to be a prime pitfall in curing cancers. Therefore, to achieve a better therapeutic efficacy, the use of a target-specific delivery, combined with a stimuli-responsive nanocarrier system, particularly pH-sensitive nanosystems offer an attractive strategy. Targeted drug delivery through pH-sensitive nanosystems offer the potential to enhance the therapeutic index of anticancer agents, either by increasing the drug concentration in tumor cells and/or by decreasing the exposure in normal host tissues. Therefore, nanoscale-based drug delivery through pH-sensitive nanosystems seem to be a boon for treating gynaecological cancers (as well as other cancers) without side-effects or with least harm to normal healthy tissues.

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Synthesis of a novel thermo/pH sensitive nanogel based on salep modified graphene oxide for drug release

Cited by 56 publications

References 39 publications

Physicochemical Characterization and Controlled Release Formulation on Intercalated 2-Methyl-4-chlorophenoxy Acetic Acid-Graphite Oxide (MCPA-GO) Nanocomposite

Physicochemical Characterization and Controlled Release Formulation on Intercalated 2-Methyl-4-chlorophenoxy Acetic Acid-Graphite Oxide (MCPA-GO) Nanocomposite

A Review on pH and Temperature Responsive Gels in Drug Delivery

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