Synthesis of amphiphilic glycophospholipids based on β-cyclodextrins

Abstract

An approach to the synthesis of amphiphilic glycophospholipids based on β cyclodextrin (β CD) was proposed. Distinctive features of the proposed method are the use of highly efficient trivalent phosphorus derivatives in the first steps of the synthesis and the regioselective monophosphorylation of nonprotected β CD. The efficiency of using 13 С NMR spectroscopy for the determination of the position and number of phospholipid residues introduced into the CD composition was shown.