Synthesis of an aminoalcohol hapten for the generation of catalytic antibodies

FLóREZ-ÁLVAREZ, José; Brocklehurst, Keith; Gallacher, Gerard; Resmini, Marina

doi:10.1016/s0040-4039(01)02101-3

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Alternative Hapten Design and Selection Strategies For Hydro...1

Bait and Switch And Charged Compounds1

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“…1,2-Amino alcohol haptens 69 and 70 and zwitterionic hapten 71 were used for the immunizations that induced antibodies for catalyzing the hydrolysis of ester 72 (Scheme ) . (A possibility was discussed that the corresponding aziridine was actually used instead of amino alcohol 69 …”

Section: Alternative Hapten Design and Selection Strategies For Hydro...mentioning

confidence: 99%

“…88 (A possibility was discussed that the corresponding aziridine was actually used instead of amino alcohol 69. 89 ). These haptens have the following features: The protonated primary amine in 69 and the quaternized ammonium salt in 70 act as positive charges to generate a basic residue in the antibody combining site and form an empty cavity for the incoming water molecule.…”

Section: Bait and Switch And Charged Compoundsmentioning

confidence: 99%

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