Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities

Li, Jing; Huang, Wenlong; Zhang, Huibin; Wang, Xin-Yang; Zhou, Huiping

doi:10.1016/j.bmcl.2007.10.009

Cited by 67 publications

(45 citation statements)

References 15 publications

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“…Some studies have shown that andrographolide, its derivatives and andrograpanin showed potent inhibitory effect towards different pro-inflammatory cytokines viz. IL-1 beta, IL-6, TNF-alpha and GM-CSF [6,17,20,21]. Tsai et al reported that, andrographolide significantly attenuated phosphorylation of ERK1/2 and its upstream activators, MAP kinase-ERK kinase (MEK1/2) in C5a-induced RAW264.7 macrophages and also strongly blocked Akt phosphorylation which is a down-stream target protein for phosphatidylinositol-3-kinase (PI3K) [10].…”

Section: Discussionmentioning

confidence: 96%

“…Andrograpanin is a minor compound and a hydrolysate obtained from neoandrographolide [5]. As reported by Li et al [6] 14-hydroxy of andrographolide is rearranged to form isoandrographolide, which is chemically more stable than andrographolide. Flavones like 7-O-methylwogonin and skullcapflavone-I have been reported to be isolated from the whole plant of A. elongata [7].…”

Section: Introductionmentioning

confidence: 90%

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In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract

Chandrasekaran

Thiyagarajan

Deepak

et al. 2011

International Immunopharmacology

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 90%

In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract

Chandrasekaran

Thiyagarajan

Deepak

et al. 2011

International Immunopharmacology

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“…Additionally, AP decreased the oxidative stress and the decreased levels of TNF-alpha and IL-6, as compared to the BDL rats. The inhibitory effects of AP on IL-6 [27] and TNF-alpha production [27,28] have been previously reported. In the current study, the levels of IL-6 and TNF-alpha were significantly elevated due to BDL, while AP treatment markedly reduced these cytokine levels.…”

Section: Discussionmentioning

confidence: 91%

Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis

Lee

Chang

2010

Apoptosis

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Bile acid-induced apoptosis plays an important role in the pathogenesis of cholestatic liver disease, and its prevention is of therapeutic interest. The aim of this study was to test whether the andrographolide limits the evolution of apoptosis in a murine model of bile duct ligation (BDL)-induced hepatic fibrosis. Male Sprague-Dawley rats were divided into four groups and hepatic apoptosis was induced by BDL for 2 weeks. The BDL animals were also treated with andrographolide (50, 100, and 200 mg/kg, i.p.) during the same time period. BDL-induced liver injury was associated with apoptosis and fibrosis, and the latter was significantly reduced in animals receiving andrographolide. The increase in serum alanine aminotransferase, asparate aminotransferase, tumor necrosis factor-alpha and IL-1beta levels caused by BDL were also significantly reduced by treatment with andrographolide. Andrographolide decreased the intrahepatic protein levels of cannabinoid receptor 1 (CB1), Bax, and cytochrome c, along with of alpha-smooth muscle actin (alpha-SMA) and transforming growth factor-beta (TGF-beta), two markers of fibrogenesis. This effect was mediated by the inactivation of the c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK1/2) phosphorylation cascade, but it did not affect the p38 mitogen-activated protein kinase pathway. Additionally, andrographolide reduced the generation of hepatic lipid peroxidation and enhance senescence marker protein-30 levels to resist the hepatic oxidative stress in the presence of BDL. In conclusion, this study has identified AP as a potent protector against cholestasis-induced apoptosis in vivo. Its anti-apoptotic action largely relies on the inhibition of the oxidative stress pathway.

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“…Andrographolide (andro) is a labdane diterpenoid, the main bioactive component of the medicinal plant Andrographis paniculata. Andro is known to have anti-fibrotic, antiinflammatory, and anti-cancerous properties (Akbarsha and Murugaian, 2000;Lee et al, 2010;Li et al, 2007;Rana and Avadhoot, 1991;Shen et al, 2009Shen et al, , 2000. Therefore, we hypothesize that andro can inhibit proliferation and migration of the lens epithelial cell line (FHL 124).…”

mentioning

confidence: 86%

Andrographolide reduces proliferation and migration of lens epithelial cells by modulating PI3K/Akt pathway

Kayastha¹,

Madhu²,

Vasavada³

et al. 2014

Experimental Eye Research

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Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities

Cited by 67 publications

References 15 publications

In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract

In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract

Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis

Andrographolide reduces proliferation and migration of lens epithelial cells by modulating PI3K/Akt pathway

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