Synthesis of Aromatic Benzo‐Fused Five‐ and Six‐Membered Heterocycles via Palladium‐ and Copper‐Catalyzed CX Bond‐Forming Reactions

Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration

“…Indole skeleton is found in a large number of natural products and many of them have unique biological activity. Consequently, the indole synthesis has been a very important issue in organic chemistry . The cycloisomerization of 2-alkynylanilines is an efficient method for the synthesis of 2-substituted indoles. , In the Lewis-acid-catalyzed reaction, the cyclization proceeded by the nucleophilic attack of the amino group to the activated alkynyl moiety (Scheme a).…”