Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)

Rosari, Venansia Avelia; Lestari, Witri Wahyu; Firdaus, Maulidan

doi:10.1007/s11696-020-01114-4

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Combination of these two active substances is allowed in Poland if the form of the drug is tablets that contain up to 500 mg of acetylsalicylic acid and 200 mg of glycine. Acetylsalicylic acid (ASA) represents the non-steroidal anti-inflammatory drugs and inhibits the activity of oxygenase by acetylation of the serine residue, exerting analgesic, antipyretic and anti-inflammatory effects 7 , 8 . It also prevents platelet aggregation, reducing the risk of ischemic stroke and heart attack 9 .…”

Section: Introductionmentioning

confidence: 99%

Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product

Kowalska

Woźniak

Kijek³

et al. 2022

Sci Rep

1,842

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The work mainly focused on a validation of the method for determining the content of salicylic acid and individual unknown impurities in new pharmaceutical product—tablets containing: 75, 100 or 150 mg of acetylsalicylic acid and glycine in the amount of 40 mg for each dosage. The separation of the components was carried out by means of HPLC, using a Waters Symmetry C18 column (4.6 × 250 mm, 5 μm) as the stationary phase. The mobile phase consisted of a mixture of 85% orthophosphoric acid, acetonitrile and purified water (2:400:600 V/V/V). Detection was carried out at a wavelength of 237 nm, with a constant flow rate of 1.0 ml min−1. In order to verify the method, linearity, precision (repeatability and reproducibility), accuracy, specificity, range, robustness, system precision, stability of the test and standard solution, limit of quantification and forced degradation were determined. Validation tests were performed in accordance with ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) guidelines. The method was validated successfully. It was confirmed that the method in a tested range of 0.005–0.40% salicylic acid with respect to acetylsalicylic acid content is linear, precise and accurate.

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Section: Introductionmentioning

confidence: 99%

Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product

Kowalska

Woźniak

Kijek³

et al. 2022

Sci Rep

1,842

View full text Add to dashboard Cite

show abstract

“…In the CS-GO NCs, the absorption peaks at 2846, 1660, 1075, and 640 cm −1 correspond to the C−H, N−H, C−O and OC−NH vibrations, respectively. The absorption peaks of cisplatin at 598, 1670, and 1334 cm −1 correspond to the stretching vibration of Pt-N 41 and asymmetric and symmetric bendings of the N−H group, respectively. After loading CDDP to CS-GO NCs, most of the characteristic peaks were the same as the CDDP, and this confirms the loading of CDDP to CS-GO NCs.…”

Section: Resultsmentioning

confidence: 99%

Design of Bio-Graphene-Based Multifunctional Nanocomposites Exhibits Intracellular Drug Delivery in Cervical Cancer Treatment

Vasanthakumar

Rejeeth

Vivek

et al. 2022

ACS Appl. Bio Mater.

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The advent of bio-nanotechnology has revolutionized nanodrug delivery by improving drug efficacy and safety. Nevertheless, acceptable carriers for therapeutic molecules are one of the most difficult challenges in drug delivery. Graphene material-based (GMB) and polymer-based drug-loaded nanocarriers have both demonstrated clinical advantages in delivering drugs of interest in vitro/in vivo. Cisplatin (CDDP) is an inorganic chemotherapeutic drug that is commonly used to treat a variety of cancers. However, its clinical use is associated with drug resistance and few side effects, which reduces its antitumor effects. Therefore, we developed a CDDP-loaded chitosan-functionalized graphene oxide nanocomposite (CDDP@CS-GO NC)-based nanodrug delivery system (NDDS). Flow cytometry and confocal imaging show that the CDDP@CS-GO NCs lead to significantly increased intracellular drug accumulation in tumor cells. Cancer cells take up the nanocomposite via endocytosis and can generate intracellular reactive oxygen species (ROS) to increase mitochondrial membrane potential loss (Δψm) and enable cytochrome-c release, followed by the dysregulation of Bcl-2 into the cytosol and activation of caspase-3 to induce cancer cell apoptosis. In vitro experiments demonstrated the excellent cancer therapeutic effect with few side effects of the carriers. CDDP@CS-GO NCs are expected to play an important role in responsive NDDSs for cancer therapy.

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Applications of Material Institute Lavoisier (MIL) based materials as nano drug delivery carriers in biomedicine

Wang,

Gao,

Zhao

et al. 2024

Coordination Chemistry Reviews

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Synthesis of aspirin-ligated cisplatin derivatives and its slow release study over MIL-101(Fe)

Cited by 4 publications

References 37 publications

Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product

Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product

Design of Bio-Graphene-Based Multifunctional Nanocomposites Exhibits Intracellular Drug Delivery in Cervical Cancer Treatment

Applications of Material Institute Lavoisier (MIL) based materials as nano drug delivery carriers in biomedicine

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