2008
DOI: 10.1007/s10600-008-9054-7
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Synthesis of betulonic acid amides

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Cited by 6 publications
(9 citation statements)
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“…Compounds 1 [17], 2 -6 [18], 7 [19], 8 -11, 13 -18, 21, 23 -25 [18], 12, 19, 20 [21], 22 [22], 26, 27 [23], 28 [16], 29 -33 [17], 34 [24], 35 [25], 36, 38 [24], 39, 40 [26], 40 -45 [20], 46, 47 [27], 48 [28] obtained according to the previously described methods. (20 mL), and the mixture was stirred for 2 h at room temperature, then the solvent was removed in vacuo.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Compounds 1 [17], 2 -6 [18], 7 [19], 8 -11, 13 -18, 21, 23 -25 [18], 12, 19, 20 [21], 22 [22], 26, 27 [23], 28 [16], 29 -33 [17], 34 [24], 35 [25], 36, 38 [24], 39, 40 [26], 40 -45 [20], 46, 47 [27], 48 [28] obtained according to the previously described methods. (20 mL), and the mixture was stirred for 2 h at room temperature, then the solvent was removed in vacuo.…”
Section: Methodsmentioning
confidence: 99%
“…To continue our efforts towards developing new promising antiviral agents among triterpenoids [10][11][12][16][17][18][19][20][21], here we present new data on in vitro antiviral screening of a broad series of nitrogen lupane triterpenoids modified at C3, C20 and C28 positions ( Figure 1) in relation to their activity against Flu A (H1N1, H3N2 and H5N1). Forty-seven derivatives (1-36, 38-48) have been synthesized as described previously [16][17][18][19][20][21][22][23][24][25][26][27][28], while four compounds (37, 49-51) are new.…”
mentioning
confidence: 99%
“…Betulonic acid diethylentriamine conjugate showed partial activity against methicillin-resistant S. aureus and the fungi C. neoformans [265]. [265,275], 268 [281], 269 [265], 270, 271 [300], 272, 273, 290 [298], 275, 299 [299], 276 [294,303], 277 [258], 278 [259], 279 [260], 280 [295,299], 281, 292 [302], 282 [289], 283 [274], 284 [304], 285 [287], 286 [291], 287 [284], 288 [277], 289 [285], 291 [283], 293 [296], 294 [280], 295 [297], 296 [279], 297 [274].…”
Section: Terpene-and Triterpene-based Polyamine Derivativesmentioning
confidence: 99%
“…It is an available and convenient starting material for synthesizing new biologically active compounds [3][4][5][6]. Compounds with antioxidant, anti-inflammatory, antibacterial, hepatoprotective, antiviral, antitumor, and immunostimulant properties have been found among the synthesized derivatives of betulonic acid [4,[7][8][9][10][11][12].…”
mentioning
confidence: 99%
“…The yields of the target compounds were 74.9-89.8%. The structures of the amides were established using IR and NMR spectra and a comparison with those for analogous compounds [5,6,12]. The 13 C NMR spectra of the synthesized compounds 2-7 contained resonances for the betulonic moiety and the corresponding number of C resonances for the amine component (Table 1).…”
mentioning
confidence: 99%