Synthesis of Biogenic Copper Nanoparticles Embedded in Graphene Oxide-Chitosan Composite and Its Anti-Bacterial and Cytotoxic Activities

Mugesh, Subramanian; Renganathan, R.R. Arun; Arunkumar, K.; Murugan, Marudhamuthu

doi:10.1166/jnn.2019.15887

Cited by 12 publications

(3 citation statements)

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“…Hence, the application of GBNs in the drug delivery field should focus on modifying their surface chemistry to improve their biocompatibility with cells and biomacromolecules. Strategies to functionalize GBNs, such as coating with polyethylene glycol [98], chitosan [99], or FA [47], have been reported. In addition to the common modifications mentioned above, some new routes have been developed.…”

Section: Modifications For Better Biocompatibilitymentioning

confidence: 99%

Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

Cui

Lin

et al. 2021

J Nanobiotechnol

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Breast cancer is the most common malignancy in women, and its incidence increases annually. Traditional therapies have several side effects, leading to the urgent need to explore new smart drug-delivery systems and find new therapeutic strategies. Graphene-based nanomaterials (GBNs) are potential drug carriers due to their target selectivity, easy functionalization, chemosensitization and high drug-loading capacity. Previous studies have revealed that GBNs play an important role in fighting breast cancer. Here, we have summarized the superior properties of GBNs and modifications to shape GBNs for improved function. Then, we focus on the applications of GBNs in breast cancer treatment, including drug delivery, gene therapy, phototherapy, and magnetothermal therapy (MTT), and as a platform to combine multiple therapies. Their advantages in enhancing therapeutic effects, reducing the toxicity of chemotherapeutic drugs, overcoming multidrug resistance (MDR) and inhibiting tumor metastasis are highlighted. This review aims to help evaluate GBNs as therapeutic strategies and provide additional novel ideas for their application in breast cancer therapy.

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Section: Modifications For Better Biocompatibilitymentioning

confidence: 99%

Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

Cui

Lin

et al. 2021

J Nanobiotechnol

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“…Considering that water is the main component in body fluids and accounts for 70 wt% of the human body, the application scenarios of water lubrication can also be extended to bio-lubrication. The mechanical properties, chemical inertness, and relative antibacterial properties [130,131] of GO materials attracted the interests of researchers to explore the potential application in bio-lubrication. Previous reports proved that the biocompatibility of GO is related to the factors such as physical-chemical properties, concentration, time of exposure and so on.…”

Section: Application Of Go In Bio-lubricationmentioning

confidence: 99%

Water lubrication of graphene oxide-based materials

Xue

Guo

et al. 2021

Friction

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Water is as an economic, eco-friendly, and efficient lubricant that has gained widespread attention for manufacturing. Using graphene oxide (GO)-based materials can improve the lubricant efficacy of water lubrication due to their outstanding mechanical properties, water dispersibility, and broad application scenarios. In this review, we offer a brief introduction about the background of water lubrication and GO. Subsequently, the synthesis, structure, and lubrication theory of GO are analyzed. Particular attention is focused on the relationship between pH, concentration, and lubrication efficacy when discussing the tribology behaviors of pristine GO. By compounding or reacting GO with various modifiers, amounts of GO-composites are synthesized and applied as lubricant additives or into frictional pairs for different usage scenarios. These various strategies of GO-composite generate interesting effects on the tribology behaviors. Several application cases of GO-based materials are described in water lubrication, including metal processing and bio-lubrication. The advantages and drawbacks of GO-composites are then discussed. The development of GO-based materials for water lubrication is described including some challenges.

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“…Therefore, it is necessary to investigate the distribution of nanoparticles in polymers, as shown in figure 4. Laser scanning confocal microscopy (LSCM) is not only a powerful tool to investigate cells, but it may also be used as a high-throughput technique for examining nanoparticle-polymer composites [44], and investigating metallic nanoparticles [4,[45][46][47]. Confocal microscopy is very sensitive to the particle's geometry and polarizability while scattering patterns of metal nanoparticles are acquired.…”

Section: Laser-based Synthesis Of Nanoparticle-loaded Alginate or Tpumentioning

confidence: 99%

Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties

Rehbock

Nachev

et al. 2020

Nanotechnology

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Nanocomposites have been widely applied in medical device fabrication and tissue-engineering applications. In this context, the release of metal ions as well as protein adsorption capacity are hypothesized to be two key processes directing nanocomposite-cell interactions. The objective of this study is to understand the polymer-matrix effects on ion release kinetics and their relations with protein adsorption. Laser ablation in macromolecule solutions was employed for synthesizing Au and Fe nanoparticle-loaded nanocomposites based on thermoplastic polyurethane (TPU) and alginate. Confocal microscopy revealed a three-dimensional homogeneous dispersion of laser-generated nanoparticles in the polymer. The physicochemical properties revealed a pronounced dependence upon embedding of Fe and Au nanoparticles in both polymer matrices. Interestingly, the total Fe ion concentration released from alginate gels under static conditions decreased with increasing mass loadings, a phenomenon only found in the Fe-alginate system and not in the Cu/Zn-alginate and Fe-TPU control system (where the effects were proportioonal to the nanoparticle load). A detailed mechanistic examination of iron the ion release process revealed that it is probably not the redox potential of metals and diffusion of metal ions alone, but also the solubility of nano-metal oxides and affinity of metal ions for alginate that lead to the special release behaviors of iron ions from alginate gels. The amount of adsorbed bovine serum albumin (BSA) and collagen I on the surface of both the alginate and TPU composites was significantly increased in contrast to the unloaded control polymers and could be correlated with the concentration of released Fe ions and the porosity of composites, but was independent of the global surface charge. Interestingly, these effects were already highly pronounced at minute loadings with Fe nanoparticles down to 200 ppm. Moreover, the laser-generated Fe or Au nanoparticle-loaded alginate composites were shown to be a suitable bioink for 3D printing. These findings are potentially relevant for ion-sensitive bio-responses in cell differentiation, endothelisation, vascularisation, or wound healing.

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Synthesis of Biogenic Copper Nanoparticles Embedded in Graphene Oxide-Chitosan Composite and Its Anti-Bacterial and Cytotoxic Activities

Cited by 12 publications

References 0 publications

Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

Water lubrication of graphene oxide-based materials

Matrix-specific mechanism of Fe ion release from laser-generated 3D-printable nanoparticle-polymer composites and their protein adsorption properties

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