Synthesis of bis(dialkylaminomethyl)-o- andm-carboranes and study of these compounds as potential preparations for boron neutron capture therapy

Zakharkin, L. I.; Ol’shevskaya, V. A.; Spryshkova, R. A.; Grigor’eva, E. Yu.; Ryabkova, V. I.; Borisov, G. I.

doi:10.1007/bf02524408

Cited by 9 publications

(2 citation statements)

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“…BNCT was primarily used for head and neck cancer treatment [27,28], but improvements of the method turned it into a promising therapy for soft tissues, like breast cancer [29], glioblastoma [30], melanomas of the skin, and liver metastases [31]. However, BNCT has limitations, which are the high concentration of thermal neutrons in the order of 10 n/cm 2 and high concentration of boron-10 in the tumor (20–35 μg per 1 g of tissue) [32,33]. These drawbacks can be improved by the immobilization of different boron-rich compounds, such as carboranes, into carriers such as micelles [34], monoclonic antibodies [35], liposomes [36,37], carbon nanotubes [38], gold nanoparticles [39], and magnetic nanostructures [40,41].…”

Section: Introductionmentioning

confidence: 99%

Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

et al. 2019

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Magnetic Fe3O4 nanoparticles (NPs) and their surface modification with therapeutic substances are of great interest, especially drug delivery for cancer therapy, including boron-neutron capture therapy (BNCT). In this paper, we present the results of boron-rich compound (carborane borate) attachment to previously aminated by (3-aminopropyl)-trimethoxysilane (APTMS) iron oxide NPs. Fourier transform infrared spectroscopy with Attenuated total reflectance accessory (ATR-FTIR) and energy-dispersive X-ray analysis confirmed the change of the element content of NPs after modification and formation of new bonds between Fe3O4 NPs and the attached molecules. Transmission (TEM) and scanning electron microscopy (SEM) showed Fe3O4 NPs’ average size of 18.9 nm. Phase parameters were studied by powder X-ray diffraction (XRD), and the magnetic behavior of Fe3O4 NPs was elucidated by Mössbauer spectroscopy. The colloidal and chemical stability of NPs was studied using simulated body fluid (phosphate buffer—PBS). Modified NPs have shown excellent stability in PBS (pH = 7.4), characterized by XRD, Mössbauer spectroscopy, and dynamic light scattering (DLS). Biocompatibility was evaluated in-vitro using cultured mouse embryonic fibroblasts (MEFs). The results show us an increasing of IC50 from 0.110 mg/mL for Fe3O4 NPs to 0.405 mg/mL for Fe3O4-Carborane NPs. The obtained data confirm the biocompatibility and stability of synthesized NPs and the potential to use them in BNCT.

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Section: Introductionmentioning

confidence: 99%

Fe3O4 Nanoparticles for Complex Targeted Delivery and Boron Neutron Capture Therapy

et al. 2019

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“…Nevertheless, an important condition for BNCT technology is the achievement of a high concentration of boron carriers in the tumors, for which the design and selection of boron carriers is critical. [ 256 ] Furthermore, increasing drug blood–brain barrier penetration is a major issue in the treatment of brain diseases. Encouragingly, research has found that nanosheets with photothermal effects, such as black phosphorus, can effectively promote drug blood–brain barrier penetration through photothermal effects, and promote the treatment of Alzheimer's disease and depression.…”

Section: Perspectivementioning

confidence: 99%

The Emergence and Evolution of Borophene

et al. 2021

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Neighboring carbon and sandwiched between non‐metals and metals in the periodic table of the elements, boron is one of the most chemically and physically versatile elements, and can be manipulated to form dimensionally low planar structures (borophene) with intriguing properties. Herein, the theoretical research and experimental developments in the synthesis of borophene, as well as its excellent properties and application in many fields, are reviewed. The decade‐long effort toward understanding the size‐dependent structures of boron clusters and the theory‐directed synthesis of borophene, including bottom‐up approaches based on different foundations, as well as up‐down approaches with different exfoliation modes, and the key factors influencing the synthetic effects, are comprehensively summarized. Owing to its excellent chemical, electronic, mechanical, and thermal properties, borophene has shown great promise in supercapacitor, battery, hydrogen‐storage, and biomedical applications. Furthermore, borophene nanoplatforms used in various biomedical applications, such as bioimaging, drug delivery, and photonic therapy, are highlighted. Finally, research progress, challenges, and perspectives for the future development of borophene in large‐scale production and other prospective applications are discussed.

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