Synthesis of Bis(indolyl)methane/Dihydropyrimidinone Tethered Bis‐Amidic Triazole Hybrid Compounds via One‐Pot Sequential Six/Seven Component Ugi‐Click Reaction

Abstract

Synthesis of bis(indolyl)methane/dihydropyrimidinone based bis‐amide‐triazole hybrid compounds has been achieved via one‐pot six/seven‐component sequential Ugi‐Click reaction. Two molecular libraries of anti‐bacterial compounds containing significant pharmacophoric nuclei were synthesized in good yield and purity using green solvent, mild reaction conditions with atom economy by structural modifications in three independent starting materials.

Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

“…26 Singh et al also recently used this strategy for the synthesis of bis(indolyl)methane/dihydropyrimidinone based bis-amide-triazole hybrid compounds. 27…”

“…26 Singh et al also recently used this strategy for the synthesis of bis(indolyl)methane/dihydropyrimidinone based bis-amide-triazole hybrid compounds. 27 Because of our interests in the design of combinatorial MCRs 28 and inspired by the above-discussed biological importance of structures containing quinoxaline-pseudopeptide-triazole functionalities, herein, we report a sustainable one-pot, sixcomponent, tandem cyclocondensation/Ugi/click reaction sequence based on the higher-order MCR strategy to economically unify all three pharmacophoric elements into a sole structure.…”