Synthesis of Caffeic Acid Amides Bearing 2,3,4,5-Tetra-hydrobenzo[b][1,4]dioxocine Moieties and Their Biological Evaluation as Antitumor Agents

Abstract

was also determined by single-crystal X-ray diffraction analysis. Compound D 9 was found to be a potential antitumor agent according to biological activity, molecular docking, apoptosis assay and inhibition of HepG2.

Thermodynamic study of crown ether–lithium/magnesium complexes based on benz-1,4-dioxane and its homologues

“…The synthetic routes were adapted/modified from the work of Y.-F. Ji et al 37 and H.-L. Zhu. 38 Since these CEs have not been previously considered as ligands, sufficient analysis of these structures is performed by nuclear magnetic resonance (NMR) spectroscopy (Fig. 4) and infrared (IR) spectroscopy (Fig.…”

Inhibiting Two Cellular Mutant Epidermal Growth Factor Receptor Tyrosine Kinases By Addressing Computationally Assessed Crystal Ligand Pockets

“…There is an urgent need to discover and develop new potent anti-non-small cell lung cancer (NSCLC) medications for both primary tumors and tumor with acquired resistance [1][2][3]. Many efforts aim to inhibit overexpression of EGFR [4][5][6][7]. Abnormal high activation of receptor tyrosine kinases (RTKs) is involved in carcinogenesis and tumor progression (pro-proliferative and cell survival) [2,3,8,9].…”