Synthesis of calcium carbonate-quince bio-composite for programmed and on-demand drug release of paracetamol at target site: a green chemistry approach

Abstract

In this study, an inorganic–organic composite system was developed through biomineralization of calcium carbonate in the quince-seed mucilage-based hydrogel. Drug-polymer interactions were studied by FTIR, DSC, XRD and SEM analysis. The water absorption capacity was calculated by swelling index. Drug release was determined at various pH. Several in vitro kinetic models were applied to observe drug release behaviour. Studies of drug-polymer interactions and particle flow characteristics of the developed composite material have shown that there is good compatibility between drug and the excipients. The XRD and SEM results confirmed calcite polymorphs in the developed composite material. Thermograms showed that the developed composite material was heat stable. A restricted drug release was observed in an acidic medium (pH 1.2). A controlled drug release was depicted from the developed system at pH 6.8. The drug release mechanism of Super Case II was suggested. The developed system was considered to be an effective drug carrier for colon targeted oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) to avoid gastric irritation and risk of ulceration. Graphical abstract An illustration of extraction of quince hydrogel and development of calcium carbonate-quince (CaCO 3 -Q) composite system; QSM = Quince seed mucilage Supplementary Information The online version contains supplementary material available at 10.1007/s00289-022-04400-1.

Colon Delivery of Nutraceutical Ingredients by Food-Grade Polymeric Systems: An Overview of Technological Characterization and Biological Evaluation

“…DSC allows to assess the temperatures at which characteristic endothermic and exothermic transitions occur and that are specific for a certain substance and its structure. These can indicate the melting point of the sample or more generally a state transition (e.g., a rubbery-glass transition) and its purity, and confirm any interactions between samples in mixture or neostructured in a carrier system [103][104][105].…”

“…), number and type of simulated environments (mouth, stomach, intestine, colon and any other specific sections) and their specific reference parameters (simulated environment in empty or fed conditions, pH, travel time, volumes and fluid composition, thus presence or absence of specific enzymes, surfactants, salts, etc.) [7,46,104,[116][117][118][119][120]. Added to this is the common research effort to develop in vitro dissolution/release equipment/protocols with increasing significance and predictivity of the in vivo process [121][122][123].…”

Application of Calcium Carbonate as a Controlled Release Carrier for Therapeutic Drugs

“…The prepared coreshell drug carrier can delay the rate of drug release. Kulsoom et al [28] reported on the development of a composite system prepared by biomineralization of calcium carbonate in mucilage obtained from seeds of naturally occurring quince plants. The developed composite showed restricted release of paracetamol in the acidic media, while a controlled fashion of drug release was observed in the basic media over a period of 12 h. Study outcomes suggested that the developed composite can be considered a novel drug carrier system for oral colon-targeted delivery of hydrophilic/hydrophobic drugs.…”

Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems

“…Excess AP can cause acute liver damage. Moreover, AP is one of the most commonly used medicines causing acute liver injury and is the leading cause of acute liver failure as its elimination half-life is approximately 2 h for therapeutic doses [3][4][5][6]. Regular use of AP is essential for analgesic and antipyretic support in patients with fever and discomfort.…”