Synthesis of cellulose diacetate based copolymer electrospun nanofibers for tissues scaffold

Liang, Wencheng; Hou, Jia Yu; Fang, Xiangchen; Bai, Fudong; Zhu, Tonghe; Gao, Feifei; Wei, Chao; Mo, Xiumei; Lang, Meidong

doi:10.1016/j.apsusc.2018.02.087

Cited by 30 publications

(12 citation statements)

References 41 publications

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“…[45,46] On the spectrum of pure CDA-g-PET (Figure 1b), the bands at 1,747; 1,372; 1,232; 1,045; and 900 cm −1 were assigned to C O, CH 2 (bending vibration), C O, ring of cellulose ether, and Ar-H, respectively, which represented the successful synthesis of CDA-g-PET. [40] And these characteristic peaks of Type I collagen and CDA-g-PET were all found in the spectra of Figure 1c-f, which was a crucial evidence to demonstrate the existence of both Type I collagen and CDA-g-PET in the composites. Furthermore, the broad peak at 3,396 cm −1 in the spectrum of Figure 1a was assigned to OH and NH groups in Type I collagen, while the broad peak at 3,487 cm −1 in the spectrum of Figure 1b was assigned to OH groups in CDA-g-PET.…”

Section: Ftir Spectroscopymentioning

confidence: 64%

“…The mechanical property played a key role in biomedical applications. As the report in our team's past work, [40] the tensile strength of grafted polymer CDA-g-PET was obviously improved than CDA, proved CDA-g-PET was a material with excellent mechanical properties. As shown in Table 2, the tensile strength of the composite nanofibrous mats was significantly increased from 1.976 ± 0.015 MPa to 2.440 ± 0.035 MPa as the content of Type I collagen increased, indicating that the mechanical properties of composite nanofibrous mats were enhanced further than CDA-g-PET nanofibrous film.…”

Section: Mechanical Propertymentioning

confidence: 71%

“…The preparation method of CDA-g-PET proposed by Lang et al was used, [40] the specific steps were as follows: PET with single-end hydroxyl groups was dissolved into C 2 H 2 Cl 4 under nitrogen atmosphere by stirring at 70 C to obtain a homogeneous solution. Then, IPDI (coupling reagent), DBTDL, and [Bmim]Cl (catalysts) were added to the PET solution and stirred for 2 hr to obtain the PET with isocyanate group.…”

Section: Preparation Of Cda-g-petmentioning

confidence: 99%

“…[38,39] CDA-g-PET is a novel CDA-based copolymer with improved mechanical strength, good biocompatibility, and well heat resistant ability. [40] It has been proved that CDA-g-PET could be spun as uniform and smooth nanofibers. However, the surface of the nanofibrous membranes is hydrophobic, which resulted in the prevention of cells adhesion which is prerequisite for further cells migration, differentiation, and proliferation.…”

Section: Introductionmentioning

confidence: 99%

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Co‐electrospun cellulose diacetate‐graft‐poly(ethylene terephthalate) and collagen composite nanofibrous mats for cells culture

Gao

Jiang

Liang

et al. 2020

J of Applied Polymer Sci

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In this study, a kind of novel composite nanofibrous mats with cellulose diacetate‐graft‐poly(ethylene terephthalate) (CDA‐g‐PET) and Type I collagen were obtained by electrospinning and five different ratios of CDA‐g‐PET/Type I collagen (1:0, 1:0.1, 1:0.2, 1:0.3, 1:0.4) were set to explore the effects of components on its properties. The scanning electron microscope images demonstrated that the formation of uniform and smooth nanofibers with free beads. Compared with pure CDA‐g‐PET mats, the composite materials transformed into hydrophilic ones with increasing the content of Type I collagen. Moreover, the tensile strength of the composite nanofibrous mats got higher, while its water vapor transmission rate got lower after blending with Type I collagen. In addition, the cell proliferation and adhesion on composite nanofibrous mats were improved according by the results of bone marrow mesenchymal stem cells (BMSCs) culturing experiments. Especially, the cells growth attained optimum when the CDA‐g‐PET/Type I collagen ratio reached 1:0.3 and 1:0.4, where showed no significant difference. In consequence, the above results indicated that the novel composite nanofibrous mats consisted of CDA‐g‐PET and Type I collagen obtained by electrospinning combined good mechanical strength of CDA‐g‐PET and excellent biological functions of Type I collagen. The nanoscale structure might mimic the nanofibrous extracellular matrix feature, which present the potential use in cells culture.

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Section: Ftir Spectroscopymentioning

confidence: 64%

Section: Mechanical Propertymentioning

confidence: 71%

Section: Preparation Of Cda-g-petmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Co‐electrospun cellulose diacetate‐graft‐poly(ethylene terephthalate) and collagen composite nanofibrous mats for cells culture

Gao

Jiang

Liang

et al. 2020

J of Applied Polymer Sci

Self Cite

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“…The core-shell structure, comprising two different sections with an inner-outer spatial relationship, is probably the most commonly used starting point for designing functional nanomaterials [31][32][33]. In pharmaceutics, it can provide a series of strategies for resolving challenges such as avoiding an initial burst release, protecting easily-degraded drugs from the environment, targeting release, and manipulating spatiotemporal drug release profiles [34][35][36][37][38]. To the best of our knowledge, there are no reports where electrosprayed particles have been prepared using a drug-loaded shell to control the drug release profile and where the core section serves as a support.…”

Section: Introductionmentioning

confidence: 99%

Immediate release of helicid from nanoparticles produced by modified coaxial electrospraying

Zheng

Yang

et al. 2019

Applied Surface Science

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In this paper, a modified coaxial electrospraying process was explored for the generation of novel nanoscale composite materials. A solution comprising 5% (w/v) of the model drug helicid and 10% (w/v) polyvinylpyrrolidone (PVP) K10 in a mixture of N,N-dimethylacetamide and ethanol (4:6, v:v) was employed as the shell working liquid.This could not be processed into a solid product when processed by single-fluid electrospraying. However, when undertaking co-axial electrospraying with a core shellac solution (40% w/v in ethanol) solid particles were obtained. An extremely thin nanocoating layer of drug-polymer composite with an estimated thickness of 7 nm was deposited on a shellac core. X-ray diffraction and infrared spectroscopy demonstrated that the drug was converted into an amorphous nanocomposite with the PVP in the shell layer, losing its original crystalline state. In vitro dissolution tests revealed that all the helicid loading could be released within one minute, suggesting the particles have potential applications to deliver very rapid therapeutic effects. Mechanisms are proposed underlying the formation and functional performance of the materials.

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Low-Temperature Air Plasma Modification of Electrospun Soft Materials and Bio-interfaces

Tucker

Surolia

Baker

et al. 2019

The Minerals, Metals &Amp; Materials Series

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Synthesis of cellulose diacetate based copolymer electrospun nanofibers for tissues scaffold

Cited by 30 publications

References 41 publications

Co‐electrospun cellulose diacetate‐graft‐poly(ethylene terephthalate) and collagen composite nanofibrous mats for cells culture

Co‐electrospun cellulose diacetate‐graft‐poly(ethylene terephthalate) and collagen composite nanofibrous mats for cells culture

Immediate release of helicid from nanoparticles produced by modified coaxial electrospraying

Low-Temperature Air Plasma Modification of Electrospun Soft Materials and Bio-interfaces

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