Synthesis of chalcone derivatives on steroidal framework and their anticancer activities☆

Saxena, Hari Om; Faridi, Uzma; Kumar, Jonnala Kotesh; Luqman, Suaib; Darokar, Mahendra P.; Shanker, Karuna; Chanotiya, Chandan Singh; Gupta, Madhuri; Negi, Arvind S.

doi:10.1016/j.steroids.2007.07.012

Cited by 95 publications

(46 citation statements)

References 34 publications

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“…Cell survival was calculated using the formula: Survival (%)=[(absorbance of treated cells-absorbance of culture medium)/(absorbance of untreated cells -absorbance of culture medium)] × 100 [18,19]. The experiment was done in triplicate and the inhibitory concentration (IC) values were calculated from a dose response curve.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Evaluation and DNA Binding Ability of Catalytically Synthesized New Steroidal Lactones

Mashrai¹,

Dar²,

Mir³

et al. 2017

Nat Prod Chem Res

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In an attempt to find a new class of cytotoxic agents, a series of fused steroidal derivatives containing lactone moiety were prepared via Michael addition reaction of α, β-unsaturated steroidal ketones with ethyl chloroacetate in basic medium. The characterization of novel compounds was accomplished by spectroscopic techniques such as IR, 1 H NMR, 13 C NMR, Mass spectrometry and elemental analysis. The compounds were screened for in vitro cytotoxicity against some particular human cancer cell lines using the MTT assay during which the compound 4 and 5 depicted potential anticancer behavior after showing IC 50 =19.41 μmol L −1 and 19.27 μmol L −1 against HeLa and MCF-7 cell line, respectively. The Gel electrophoresis demonstrated that steroidal lactone showed strong interaction during the concentration dependent cleavage activity with pBR322 DNA. The molecular docking study suggested the non-covalent bonding of steroidal lactones in minor groove of DNA. The results revealed that the synthesized compounds have better prospectus to act as cancer chemotherapeutic candidates which warrants further in vivo anticancer investigations.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic Evaluation and DNA Binding Ability of Catalytically Synthesized New Steroidal Lactones

Mashrai¹,

Dar²,

Mir³

et al. 2017

Nat Prod Chem Res

View full text Add to dashboard Cite

show abstract

“…Cell survival was calculated using the formula: Survival (%) = [(absorbance of treated cells -absorbance of culture medium) / (absorbance of untreated cells -absorbance of culture medium)] × 100 [26]. The experiment was done in triplicate and the inhibitory concentration (IC) values were calculated from a dose response curve.…”

Section: Discussionmentioning

confidence: 99%

In Vitro DNA-Binding, Cleavage Activity with pBR322, Molecular Docking and Antiproliferative Studies of Newly Synthesized Steroidal Imidazolidine Hybrids

Dar¹

2015

J Biomol Res Ther

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“…2-Benzylidene inden-1-one derivatives are chalcone type compounds and their bioactive potentials are quite high. They draw attention due to have bioactive properties such as monoamine oxidase inhibitors [3], AChE inhibitors [4], antiproliferative [5], anticancer [6] antioxidant activity [7] and Alzheimer's treatment [8]. In addition, they are valuable compounds from the synthetic point of view because used as starting material in the synthesis of important compounds such as indeno pyrazole [9], indeno pyrimidine [10] and indeno pyridine derivatives [11,12].…”

Section: Introductionmentioning

confidence: 99%

Alternate Method for the Dimerization of 2-Benzylidene inden-1-one Derivatives: Synthesis of 1,3-Diaryl-1,3,3a,8a-tetrahydro-8H-spiro[cyclopenta[a]indene-2,2'-indene]-1',8(3'H)-diones

Gezegen¹

2017

Cumhuriyet Science Journal

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Synthesis of chalcone derivatives on steroidal framework and their anticancer activities☆

Cited by 95 publications

References 34 publications

Cytotoxic Evaluation and DNA Binding Ability of Catalytically Synthesized New Steroidal Lactones

Cytotoxic Evaluation and DNA Binding Ability of Catalytically Synthesized New Steroidal Lactones

In Vitro DNA-Binding, Cleavage Activity with pBR322, Molecular Docking and Antiproliferative Studies of Newly Synthesized Steroidal Imidazolidine Hybrids

Alternate Method for the Dimerization of 2-Benzylidene inden-1-one Derivatives: Synthesis of 1,3-Diaryl-1,3,3a,8a-tetrahydro-8H-spiro[cyclopenta[a]indene-2,2'-indene]-1',8(3'H)-diones

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