Synthesis of chemically cross-linked polyvinyl alcohol-co-poly (methacrylic acid) hydrogels by copolymerization; a potential graft-polymeric carrier for oral delivery of 5-fluorouracil

Abstract

Background of the StudyThe propose of the present work was to develop chemically cross-linked polyvinyl alcohol-co-poly(methacrylic acid) hydrogel (PVA-MAA hydrogel) for pH responsive delivery of 5-Fluorouracil (5-FU).MethodsPVA based hydrogels were prepared by free radical copolymerization. PVA has been cross-linked chemically with monomer (methacrylic acid) in aqueous medium, cross-linking agent was ethylene glycol di-methacrylate (EGDMA) and benzoyl peroxide was added as reaction initiator. 5-FU was loaded as model drug. FTIR, XRD, TGA and DSC were performed for characterization of copolymer. Surface morphology was studied by SEM. pH sensitive properties were evaluated by swelling dynamics and equilibrium swelling ratio at low and higher pH.ResultsFTIR, XRD, TGA and DSC studies confirmed the formation of new copolymer. Formulations with higher MAA contents showed maximum swelling at 7.4 pH. High drug loading and higher drug release has been observed at pH 7.4.ConclusionsThe current study concludes that a stable copolymeric network of PVA was developed with MAA. The prepared hydrogels were highly pH responsive. This polymeric network could be a potential delivery system for colon targeting of 5-FU in colorectal cancers.

Development andIn-VitroEvaluation of pH Responsive Polymeric Nano Hydrogel Carrier System for Gastro-Protective Delivery of Naproxen Sodium

“…is comparative analysis indicated that the drug (Naproxen) is in intact form as major peaks were in their original position i.e. 1033 cm −1 and 1571 cm −1 as in pure drug and the drug is physically entrapped in nanogels particulate systems as previously reported by Minhas et al [43].…”

Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)

“…As demonstrated by Minhas et al (2013), the PVA shows a characteristic sharp peak at 2θ = 20 and the hydrogel of PVA cross‐linked with methacrylic acid had a change in the XRD pattern with a decrease of the peak at 2θ = 20° and maintaining a broad peak at 2θ = 40.0°. In addition, the XRD pattern showed a decrease in the hydrogel crystallinity after cross‐linking . Another study presented the reduction of the crystallinity index (ratio of the areas) of the PVA after reticulation with GLUT …”

High performance biocompatible cellulose‐based microcapsules encapsulating gallic acid prepared by inverse microsuspension polymerization

“…Due to the reactive C=C moieties along the m‐CMC side chains, the material underwent radical polymerization with MAA, obtaining biocompatible grafted m‐CMC products (m‐CMC‐ g ‐PMAA). When the grafted PMAA chains were formed, the m‐CMC‐ g‐ PMAA microcapsule shell was formed with a three‐dimensional (3D) network by both covalent crosslinking and hydrogen bonding . High monomer conversions ( ca 80%) were obtained for all ratios of m‐CMC:MAA (w/w %).…”