Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs

Hanessian, Stephen; Grzyb, Justyna A.; Cengelli, Feride; Juillerat‐Jeanneret, Lucienne

doi:10.1016/j.bmc.2007.12.051

Cited by 45 publications

(31 citation statements)

References 19 publications

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“…72 In particular, natural and synthetic polymers as well as poly-ethylene-glycol moieties could be end-functionalized for chemical modification to increase the delivery across the BBB. 109,110 A. Polymeric Nanoparticles An important field of application for polymeric NPs is the delivery of compounds to the CNS. Their size can limit their diffusion through the BBB and cause failure to reach the brain parenchyma.…”

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confidence: 99%

Nanoparticulate devices for brain drug delivery

et al. 2010

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The blood-brain barrier (BBB) limits the transport of therapeutic molecules from the blood compartment into the brain, thus greatly reducing the species of therapeutic compounds that can be efficiently accumulated in the central nervous system (CNS). Various strategies have been proposed for improving the delivery of drugs to this tissue, and numerous invasive and noninvasive methods have been proposed by different scientists in an attempt to circumvent the BBB and to increase the delivery of drug compounds into the brain. An interesting alternative, in the solution of this problem and also that of reaching a suitable target in the CNS, has recently been provided through the use of nanoparticulate colloidal devices as a noninvasive technique for brain drug delivery. These systems offer diverse advantages over invasive strategies, because (1) they are designed using biocompatible and biodegradable materials; (2) they avoid the disruption and/or modification of the BBB; and (3) they modulate the biopharmaceutical properties of the entrapped drugs. Moreover, the possibility of targeting specific brain tissue, thanks to ligands linked to the surface of the nanoparticulate colloidal devices, confers the necessary characteristics for the treatment of CNS pathologies to these drug carriers. The aim of this review is to focus on describing the main strategies in use for designing nanoparticulate colloidal devices for CNS delivery, their potentiality as noninvasive strategies in the delivery of drugs to the cerebral tissues, and their biological and clinical applications in cerebral drug delivery.

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Nanoparticulate devices for brain drug delivery

et al. 2010

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“…In particular, we had observed that the intracellular localization of cationic USPIO NPs functionalized with hydrophilic or hydrophobic drugs was dependent on the lipophilicity of the drugs. 10,11 We have also previously shown that monolayers and spheroids of human colon cells can internalize cationic USPIO NPs, but cannot release or transport them across models of the human colon epithelial barrier. 12 In the present study, in order to further evaluate the effects of the biophysical characteritics of USPIO NPs in human colon cells, we compared the reaction of human HT29 and CaCo 2 colon epithelial cells to deeply characterized non-stabilized (bare) and oleic-acid-stabilized USPIO NPs, demonstrating that the main colon cell stress response was the induction of high amounts of large lipid vacuoles dependent on the oleic acid stabilizer of the USPIO NPs, but not on free oleic acid or the iron oxide core.…”

Section: Introductionmentioning

confidence: 99%

“…Their uses have been recently extended to new applications. [4][5][6][7] We have previously shown that USPIO NPs are taken up by human cells, even when functionalized with a fluorophore 8,9 or with therapeutic anticancer agents, 10,11 but that the biochemical characteristics of the surface functionalization of the NPs were important for their cellular trafficking and the reaction of the cells to their uptake. In particular, we had observed that the intracellular localization of cationic USPIO NPs functionalized with hydrophilic or hydrophobic drugs was dependent on the lipophilicity of the drugs.…”

Section: Introductionmentioning

confidence: 99%

Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles

Schütz¹,

Staedler²,

Crosbie-Staunton³

et al. 2014

IJN

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Therapeutic engineered nanoparticles (NPs), including ultrasmall superparamagnetic iron oxide (USPIO) NPs, may accumulate in the lower digestive tract following ingestion or injection. In order to evaluate the reaction of human colon cells to USPIO NPs, the effects of non-stabilized USPIO NPs (NS-USPIO NPs), oleic-acid-stabilized USPIO NPs (OA-USPIO NPs), and free oleic acid (OA) were compared in human HT29 and CaCo 2 colon epithelial cancer cells. First the biophysical characteristics of NS-USPIO NPs and OA-USPIO NPs in water, in cell culture medium supplemented with fetal calf serum, and in cell culture medium preconditioned by HT29 and CaCo 2 cells were determined. Then, stress responses of the cells were evaluated following exposure to NS-USPIO NPs, OA-USPIO NPs, and free OA. No modification of the cytoskeletal actin network was observed. Cell response to stress, including markers of apoptosis and DNA repair, oxidative stress and degradative/autophagic stress, induction of heat shock protein, or lipid metabolism was determined in cells exposed to the two NPs. Induction of an autophagic response was observed in the two cell lines for both NPs but not free OA, while the other stress responses were cell- and NP-specific. The formation of lipid vacuoles/droplets was demonstrated in HT29 and CaCo 2 cells exposed to OA-USPIO NPs but not to NS-USPIO NPs, and to a much lower level in cells exposed to equimolar concentrations of free OA. Therefore, the induction of lipid vacuoles in colon cells exposed to OA utilized as a stabilizer for USPIO NPs is higly amplified compared to free OA, and is not observed in the absence of this lipid in NS-USPIO NPs.

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“…Commonly used coatings include poly(lactic-co-glycolic acid) (PLGA) [29], Polyethylene glycol (PEG) [30], Poly vinyl alcohol (PVA), [31] and pluronic-127 [32]. e efficiency of these coatings can be determined through cell viability studies at various concentrations of nanoparticles [33]. In this study a uniform superparamagnetic Fe 3 O 4 nanoparticles were synthesized and characterized for their morphology, structural, magnetic and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of Magnetic Nanoparticles for Biomedical Applications

Bolden

Rangari

Jeelani

et al. 2013

Journal of Nanoparticles

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In this study, iron oxide (IO) nanoparticles from various precursors have been synthesized using sonochemical method and characterized for their structural variability and toxicity. e iron oxide (IO) precursor solutions were prepared from iron acetate (IA), iron pentacarbonyl (IP), decalin, PEG (poly(ethylene glycol)), EG (ethylene glycol), PVA (poly(vinyl alcohol)), -cyclodextrin (CD), and distilled water. ese precursor solutions were irradiated with high power ultrasound for 3 hours and heat treated as needed. ese as-prepared iron oxide nanoparticles were characterized using X-ray diffraction (XRD), Mössbauer spectroscopy, transmission electron microscopy (TEM), and magnetization measurements. XRD results show that all the particles are highly crystalline in nature and the particles sizes measured from TEM are approximately 5-20 nm. e maximum magnetization was observed for IO-IP at approximately 60.17 emu/g and the minimum was approximately 30.56 emu/g for IO-IA. ese results con�rm that the particles are superparamagnetic (SPM) in nature. Mössbauer spectroscopy veri�ed the magnetic nanoparticles are purely Fe 3 O 4 and particles sizes varied by the nature of the precursor and coatings.

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Synthesis of chemically functionalized superparamagnetic nanoparticles as delivery vectors for chemotherapeutic drugs

Cited by 45 publications

References 19 publications

Nanoparticulate devices for brain drug delivery

Nanoparticulate devices for brain drug delivery

Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles

Synthesis and Evaluation of Magnetic Nanoparticles for Biomedical Applications

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