Synthesis of chitin calcium phosphate composite in different growth media

Geçer, Aylin; Yıldız, Nuray; Erol, Murat; Çalımlı, Ayla

doi:10.1002/pc.20385

Cited by 13 publications

(6 citation statements)

References 23 publications

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“…3). The peaks observed at 25.5°, 31.7°, and 45° belong to apatitic calcium phosphates and the peak observed at 31.7° is the most intense peak in the HA spectrum [28, 38]. According to the semiquantitative EDAX analysis, the Ca/P ratio in the aggregates was about 2.2 (data was not shown).…”

Section: Resultsmentioning

confidence: 99%

Bone‐like apatite‐coated chitosan scaffolds: Characterization and osteoblastic activity

Aday

Gümüşderelı́oğlu

2010

Polymer Composites

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In this study, porous scaffolds were prepared from chitosan (2% w/v in acetic acid and deacetylation degree: DD > 85%) by freeze-drying method, and freshly lyophilized scaffolds were stabilized with ethanol solutions. Bone-like apatite formation on chitosan scaffolds was achieved by immersing the scaffolds into a novel concentrated simulated body fluid (103 SBF-like solution) for different periods, i.e., 6 and 24 h. Scanning electron microscope views showed that the 6-h treatment in 103 SBF-like solution led to the formation of calcium phosphate nucleation sites on chitosan scaffolds, whereas the apatite particles showed characteristic cauliflowerlike morphology at the end of 24-h treatment. X-ray diffraction results supported the fact that mineral phase was made of hydroxyapatite. Osteogenic activities of untreated and SBF-treated chitosan scaffolds were examined by preosteoblastic MC3T3 cell culture studies. The mitochondrial activity test showed that apatitecoated scaffolds stimulated cell proliferation compared with uncoated scaffolds. Alkaline phosphatase and osteocalcine levels indicated that the differentiation of the cells on all scaffolds increased significantly from 15th day of culture to the 21th day of culture, especially for the cells on 24-h SBF-treated scaffolds. The results of this study indicated that 103 SBF-like solutiontreated chitosan scaffolds may be evaluated for bone tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Bone‐like apatite‐coated chitosan scaffolds: Characterization and osteoblastic activity

Aday

Gümüşderelı́oğlu

2010

Polymer Composites

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“…Various biocomposites of CaPO 4 with chitosan [ 234 , 403 , 425 , 436 , 453 , 462 , 499 , 581 , 582 , 583 , 584 , 585 , 586 , 587 , 588 , 589 , 590 , 591 , 618 , 638 , 643 , 746 , 747 , 748 , 749 , 750 , 751 , 752 , 753 , 754 , 755 , 756 , 757 ] and chitin [ 392 , 452 , 758 , 759 , 760 , 761 , 762 ] are also very popular. For example, a solution-based method was developed to combine HA powders with chitin, in which the ceramic particles were uniformly dispersed [ 758 , 759 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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“…Various biocomposites of calcium orthophosphates with chitosan 298,482,500,512,527,565,[645][646][647][648][649][650][651][652][653]674,675,690,695,799,807,[811][812][813][814][815][816][817][818][819][820][821][822][823][824][825][826][827][828] and chitin 232,476,612,[829][830][831][832][833] are also very popular. For example, a solutionbased method was developed to combine HA powders with chitin, in which the ceramic particles were uniformly dispersed.…”

Section: 725mentioning

confidence: 99%