Synthesis of chitosan coated metal organic frameworks (MOFs) for increasing vancomycin bactericidal potentials against resistant S. aureus strain

Ghaffar, Iqra; Imran, Muhammad; Perveen, Shahida; Kanwal, Tasmina; Saifullah, Salim; Bertino, Massimo F.; Ehrhardt, Christopher J.; Yadavalli, Vamsi K.; Shah, Muhammad Raza

doi:10.1016/j.msec.2019.110111

Cited by 77 publications

(31 citation statements)

References 46 publications

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“…Synthesis of CS/MOF loaded with 5-FU is demonstrated in Figure 24. Ghaffar et al [145] synthesized CS-coated MOFs with enhanced contact with S. aureus cell surface. The novel system was studied for its efficacy on resistant S. aureus.…”

Section: Carbon Nanotubes (Cnts) Compositementioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

298

142

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Section: Carbon Nanotubes (Cnts) Compositementioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

298

142

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“…Moreover, it was shown that MOF particles can be a good candidate for bactericidal application alone and as a part of composite materials resistant to bacterium strains [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it was shown that MOF particles can be a good candidate for bactericidal application alone and as a part of composite materials resistant to bacterium strains [ 15 , 16 ]. A simultaneous effect of MOF-5 and silver NPs was observed for photocatalytic disinfection activity on Escherichia Coli bacteria-infected water [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

Abramenko

Deyko

Abkhalimov

et al. 2021

IJMS

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Metal-organic frameworks (MOFs) demonstrate unique properties, which are prospective for drug delivery, catalysis, and gas separation, but their biomedical applications might be limited due to their obscure interactions with the environment and humans. It is important to understand their toxic effect on nature before their wide practical application. In this study, HKUST-1 nanoparticles (Cu-nanoMOF, Cu3(btc)2, btc = benzene-1,3,5-tricarboxylate) were synthesized by the microwave (MW)-assisted ionothermal method and characterized by X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) techniques. The embryotoxicity and acute toxicity of HKUST-1 towards embryos and adult zebrafish were investigated. To gain a better understanding of the effects of Cu-MOF particles towards Danio rerio (D. rerio) embryos were exposed to HKUST-1 nanoparticles (NPs) and Cu2+ ions (CuSO4). Cu2+ ions showed a higher toxic effect towards fish compared with Cu-MOF NPs for D. rerio. Both forms of fish were sensitive to the presence of HKUST-1 NPs. Estimated LC50 values were 2.132 mg/L and 1.500 mg/L for zebrafish embryos and adults, respectively. During 96 h of exposure, the release of copper ions in a stock solution and accumulation of copper after 96 h were measured in the internal organs of adult fishes. Uptake examination of the major internal organs did not show any concentration dependency. An increase in the number of copper ions in the test medium was found on the first day of exposure. Toxicity was largely restricted to copper release from HKUST-1 nanomaterials structure into solution.

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“…Interestingly, MOFs have free functional groups decorated on their surfaces, thus they provide opportunities for their surface functionalization or engineering. Surface engineered MOFs render unique properties, such as targeted delivery, stability, controlled release of their loaded contents, and additional biological properties (Ghaffar et al, 2019;Zhang S. et al, 2020). Many functional biological molecules can be chemically or physically conjugated or adsorbed on the surfaces of MOFs via surface engineering, thus leading to synergistic properties.…”

Section: Surface Engineered Mofs In Wound Healingmentioning

confidence: 99%

“…Interestingly, MOFs have free functional groups decorated on their surfaces, thus they provide opportunities for their surface functionalization. Surface engineered MOFs render unique properties, such as targeted delivery, stability, controlled release of their loaded contents, and additional biological properties (Ghaffar et al, 2019). Recently surface engineered MOFs have attracted a greater scientific interest for wound healing due to their intrinsic biological properties and delivery and controlled release of therapeutic agents (Zhang M. et al, 2020;Zhang S. et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Chen

Cai

et al. 2020

Front. Bioeng. Biotechnol.

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Wounds present serious medical complications and their healing requires strategies that promote angiogenesis, deposition of collagen as well as re-epithelialization of wounds. Currently used conventional wound healing strategies have become less effective due to various issues associated with them. Thus, novel strategies are needed to be developed for early and effective healing of wounds. Metal-organic frameworks (MOFs), formed by linking of metal ions through organic bridging ligands, are highly tunable hybrid materials and have attracted more considerable scientific attention due to their charming and prominent properties, such as abundant pore structures and multiple functionalities. Surface engineering of MOFs with unique ligands can overcome issues associated with conventional wound healing methods, thus resulting in early and effective wound healing. This review has been undertaken to elaborate wound healing, and the use of surface engineered MOFs for effective and rapid wound healing. The process of wound healing will be discussed followed by a detailed review of recent literature for summarizing applications of surface engineered MOFs for wound healing. MOFs wound healing will be discussed in terms of their use as antibacterial agents, therapeutic delivery vehicles, and dressing systems in wound healing.

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Synthesis of chitosan coated metal organic frameworks (MOFs) for increasing vancomycin bactericidal potentials against resistant S. aureus strain

Cited by 77 publications

References 46 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Acute Toxicity of Cu-MOF Nanoparticles (nanoHKUST-1) towards Embryos and Adult Zebrafish

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

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