Synthesis of chitosan-coated polyoxometalate nanoparticles against cancer and its metastasis

Abstract

HeLa cells, before and after treatment with nanoparticles.

Polyethyleneimine‐Polyoxometalate‐Based Supramolecular Self‐assembled pH‐Responsive Hydrogels: Formulation and in vitro Evaluation

“…The cytotoxicity potential of the embedded polyanion (hydrogel) against MCF‐7, HeLa cells and Vero cells was determined through sulphorodhamine B assay (Figure ). The obtained results show that the free polyanion exhibited dose dependent toxicity on both cancerous cell lines (MCF‐7, HeLa) while there was a minimal effect on normal Vero cells . In comparison with doxorubicin concentrations the polyanion showed more cytotoxic potential on cancerous as well as on normal Vero cells supporting the statement that the tested polyanion has better anticancer activity than some of the established anticancer drugs like cisplatin .…”

Hybrid Core–Shell Nanoparticles by “Plug and Play” Self‐Assembly

“…[22] Therefore, to render POMs more stable and less toxic to the surrounding non-targeted cells, their binding to NPs could offer high protection in ap hysiological environment and allow their delivery at the target site. [23] In this purpose, our core-shell NPs (Ø m % 63 AE 3nm) are very promisinga st he size of NP-delivery systemsist ypicallyb etween 5and 200 nm. With this size range, NPs are ablet ot arget as pecific organ with effective excretion from the kidneys and the reticuloendothelial system.…”

Nanocomposites of Polyoxometalates and Chitosan‐Based Polymers as Tuneable Anticancer Agents

“…As evident from the present study, the cytotoxic behavior of POMs upon encapsulation into chitosan or CMC matrices is not yet univocal or predictable. Encapsulation of other POMs into chitosan, such as [Cs⊂Eu 6 As 6 W 63 O 218 (H 2 O) 14 (OH) 4 ] 25– , [P 5 W 30 O 110 ] 15– , [V 10 O 28 ] 6– , [TeW 6 O 24 ] 6– , [PW 12 O 40 ] 3– , [TiW 11 CoO 40 ] 7– , and [Ti 2 PW 10 O 40 ] 7– , enhanced the cytotoxicity of the nanocomposites compared to the respective pristine POMs. On the other hand, encapsulation into CMC reduced the cytotoxic effect of [Co 4 (H 2 O) 2 (PW 9 O 34 ) 2 ] 10– , and preserved the low cytotoxicity of [Eu(β 2 ‐SiW 11 O 39 ) 2 ] 13– .…”

“…Despite the growing number of such bio‐active POMs, their clinical applications still remain to be explored, because their selectivity, toxicity and stability at physiological conditions need to be controlled individually. Drug carriers, such as liposomes or biocompatible polymeric matrices made of starch, chitosan,, and – as in our recent study – its derivative carboxymethyl chitosan were applied to reduce POM toxicity while enhancing their selectivity.…”