Synthesis of cinnamoyl glucoside derivatives and their antiproliferation activities against murine melanoma B16-F10 cell line

Metabolites analysis of the marine sponge Callyspongia affinis from Kangean Island as a potential source for anticancer candidates

“…The sponges were collected by scuba diving (3-10 m depth) from Kangean Island in the Province of East Java, Indonesia. The samples were identified at the Sepuluh Nopember Institute of Technology's Zoology and Animal Engineering Laboratory, Surabaya, Indonesia, using scanning and optical microscope studies on skeletal slides and fragmented spicule mounts by the keys of John N. A. Hooper's sponge guide (Erpenbeck et al, 2020;Umeyama et al, 2010) and identified as C. affinis. The samples were put in plastic bags containing seawater, transferred to the laboratory on ice, and then stored at −10°C.…”

“…The increase in antiproliferative ability is partly due to electronic interactions such as electron-withdrawing groups attached to the aromatic ring, electron density in the double bond structure in both alkene and aromatic structures, and the presence of heterocyclic rings (Shu et al, 2021). Table 1 shows that the EtOAc fraction contains compounds with molecular formulas indicating the presence of aromatic and heterocyclic rings.…”

“…Polyacetylene diol compounds separation results from EtOAc extract Callyspongia sp. showed antiproliferative properties against HL-60 cells with IC 50 values below 10 μg/mL (Umeyama et al, 2010).…”