Synthesis of Composites SBA-15 Mesoporous Particles Carrying Oxytocin and Evaluation of Their Properties, Functions, and In Vitro Biological Activities

Qian, Ming; Liu, Min; Duan, Mengna; Wu, Zhe; Zhou, Yanmin

doi:10.1007/s12013-014-0172-5

Cited by 7 publications

(7 citation statements)

References 27 publications

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“…The higher percentage of cell adhesion observed on the composite nanofibrous scaffold might be due to the presence of mesoporous silica SBA-15 in the nanofiber scaffold, which is said to increase cell adhesion and proliferation with its highly interconnected porous structure and cytocompatibility [45]. The results indicate that all three wt% (1, 3 and 5 wt%)-incorporated SBA-15/ PVA nanofibrous scaffolds showed a similar percentage of HaCaT cell adhesion and proliferation [46]. Even less cell adhesion was observed on the TCP and control PVA nanofiber.…”

Section: Cell Adhesion Assaymentioning

confidence: 88%

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

et al. 2020

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Fabricating and designing a scaffold is a complex and highly challenging process in the current scenario. The present study deals with the design and fabrication of electrospun Santa Barbara Amorphous (SBA)-15-incorporated polyvinyl alcohol (PVA) with curcumin, which can be used as a biomimetic nanoscaffold for skin tissue engineering. Curcumin was selected due to its effective anti-microbial and anti-inflammatory properties. SBA-15 was selected for its characteristic drug-carrying potential. Fourier transform infrared spectroscopy and x-ray diffraction characterizations of the fabricated nanofiber demonstrated the interaction of PVA, SBA-15 and curcumin. The scanning electron microscopy results depicted that the nanofiber was highly interconnected with a porous structure mimicking the extracellular matrix. The nanofibrous scaffold showed a higher percentage of cell migration, proliferation, cytocompatibility and biocompatibility with absence of cytotoxicity which was evidenced from the results of MTT assay, cell adhesion and live/dead assay using HaCaT cells. The results of the anti-bacterial test depicted that the synthesized nanofiber forms a potent material for skin wound-healing therapeutics. The in vitro drug release study performed over a period of 80 h revealed a sustained release pattern of curcumin from the SBA-15-incorporated PVA nanofiber. Finally, the in vivo results confirmed that SBA-15-incorporated PVA nanofiber with curcumin showed efficient wound-healing activities.

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Section: Cell Adhesion Assaymentioning

confidence: 88%

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

et al. 2020

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“…Quantitative data on hindered diffusion in SBA-15 and KIT-6 silicas would be very welcome, as most applications rely on effective and/or selective transport of finite-size species. Hindered diffusion concerns the immobilization of enzymes, − polyhedra, and clusters , on the internal surface of these ordered mesoporous materials, as well as the transport of bulky educts and products to and from the active surface sites , or the controlled release of drugs from the pore space. − Partial exclusion of finite-size species reduces the active surface area of a support, and when interfacial kinetics are fast, diffusive transport may become rate-limiting to the process performance. Detailed 3D electron tomography data for SBA-15 and KIT-6 silicas are still scarce in the literature.…”

Section: Introductionmentioning

confidence: 99%

Hindered Diffusion in Ordered Mesoporous Silicas: Insights from Pore-Scale Simulations in Physical Reconstructions of SBA-15 and KIT-6 Silica

et al. 2018

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The performance of SBA-15 and KIT-6 silicas as ordered mesoporous supports for heterogeneous catalysis, selective adsorption, and controlled drug release relies on their properties for diffusive transport of finite-size solutes or particles. We investigate this issue through a reconstruction–simulation approach, applied to purely mesoporous SBA-15 and KIT-6 silica samples with a mean pore size of 9.4 nm. Physical reconstruction by electron tomography confirms a highly interconnected, three-dimensional mesopore network for both samples but also reveals constrictions (both samples) and dead ends (SBA-15 only) in the supposedly uniform cylinders of the primary pore system. Pore-scale simulations of the diffusion of pointlike and finite-size tracers in the reconstructions show that a small number of bottlenecks suffices for observing a dramatic decline in the effective diffusion coefficient, accessible porosity, and pore interconnectivity with increasing tracer size. When the tracer size approaches one-third of the mean pore size, diffusive transport becomes impossible. Below this limit, KIT-6 performs better than SBA-15 but both samples are decidedly inferior to random mesoporous silicas. Our results suggest that diffusive transport in SBA-15 and KIT-6 silicas could be improved by widening intrawall pores toward the mean pore size to provide bypasses around bottlenecks in the primary pore system.

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“…Bone morphogenic protein‐2 (BMP‐2) is considered as one of the most effective and extensively used growth factor to induce osteoblast differentiation and accelerate bone regeneration. Dexamethasone (Dex) with suitable dosage can enhance the BMP‐2‐induced osteoblast differentiation . Interestingly, to strengthen this synergistic osteoinductive effect, Gan et al proposed a new strategy to enhanced bone regeneration.…”

Section: Type Of Applicationsmentioning

confidence: 99%

“…Functional receptors of OT can be found on the surface of osteoblasts, bone marrow derived mesenchymal stem cells, and adipose‐derived mesenchymal stem cells. Among other things, OT stimulates mesenchymal stem cells differentiation to osteoblasts, as well as enzymatic activity of osteoblasts . Qian et al investigated the OT loading on SBA‐15 and its release from this carrier, as well as in vitro biological activity and biological safety of this material, demonstrating that the OT/SBA‐15 complex can stimulate alkaline phosphatase activity in osteoblast cells.…”

Section: Type Of Applicationsmentioning

confidence: 99%

“…Dexamethasone (Dex) with suitable dosage can enhance the BMP-2-induced osteoblast differentiation. 60 Interestingly, to strengthen this synergistic osteoinductive effect, Gan et al 61 proposed a new strategy to enhanced bone regeneration. In this report, a pH-responsive chitosanfunctionalized mesoporous silica nanoparticles (chi-MSNs) ensemble was fabricated for dual-delivery of BMP-2 and Dex.…”

Section: Type Of Applicationsmentioning

confidence: 99%

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Silica‐based mesoporous nanobiomaterials as promoter of bone regeneration process

Shadjou

Hasanzadeh

2015

J Biomedical Materials Res

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Silica-based mesostructured nanomaterials have emerged as a full family of biomaterials with tremendous potential to address the requirements for the bone regeneration process. This review focuses on more recent advances in bone regeneration process based on silica-based mesoporous biomaterials during 2012 to January 2015. In this review, we describe application of silica-based mesoporous mesostructured nanomaterials (possessing pore sizes in the range 2-50 nm) for the bone regeneration process. We summarize the preparation methods, the effect of mesopore templates and composition on the mesopore-structure characteristics, and different forms of these materials, including particles, fibers, spheres, scaffolds, and composites. The effect of structural and textural properties of mesoporous materials on the development of new biomaterials for treatment of different bone pathologies such as infection, osteoporosis, cancer, and so forth is discussed. In addition, silica-based mesoporous bioactive glass, as a potential drug/growth factor carrier, is reviewed, which includes the composition-structure-drug delivery relationship and the functional effect on the antibacteria and tissue-stimulation properties. Also, application of different mesoporous materials on construction of 3D macroporous scaffolds for bone tissue engineering was disused. Finally, this review discusses the possibility of covalently grafting different osteoinductive agents to the silica-based mesoporous scaffold surface that act as attracting signals for bone cells to promote the bone regeneration process.

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Synthesis of Composites SBA-15 Mesoporous Particles Carrying Oxytocin and Evaluation of Their Properties, Functions, and In Vitro Biological Activities

Cited by 7 publications

References 27 publications

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

Retracted: Design and fabrication of electrospun SBA-15-incorporated PVA with curcumin: a biomimetic nanoscaffold for skin tissue engineering

Hindered Diffusion in Ordered Mesoporous Silicas: Insights from Pore-Scale Simulations in Physical Reconstructions of SBA-15 and KIT-6 Silica

Silica‐based mesoporous nanobiomaterials as promoter of bone regeneration process

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