Synthesis of Condensed Furylacetic Acids Based on Multicomponent Condensation of Heterocyclic Enols with Arylglyoxals and Meldrum's Acid

2-(2-(4-Methoxyphenyl)-4,9-dimethyl-7-oxo-7H-furo[2,3-f]chromen-3-yl)acetic Acid

“…Apparently, this differen to the low reactivity of the coumarin 1 compared with those of the previously hydroxyl derivatives. Wherein, a mixture of hydrochloric and acetic acids is used final similar to the previous works [34][35][36][37][38]. The presented method all to synthesize the target 2-(2-(4-methoxyphenyl)-4,9-dimethyl-7-oxo-7H-f f]chromen-3-yl)acetic acid 4 with a 74% yield.…”

“…A significant advantage of this approach is the ability to obtain target products in one synthetic stage [29][30][31][32][33]. It should be noted that we previously proposed a general approach to the synthesis of condensed furylacetic acids based on the multicomponent reaction of various hydroxyl derivatives with arylglyoxals and Meldrum's acid [34][35][36][37][38]. We assumed that this approach could be used to synthesize substituted furo[2,3-f ]coumarins.…”

A simple and efficient approach for the synthesis of functionalized naphtho[2,1-b]furan via an one-pot, three-component reaction between Meldrum's acid, arylglyoxals, and β-naphthol

“…Based on previous works, it was illustrated that similar synthesis of furan derivatives (Scheme 1a-f) using cyclic dicarbonyl compounds, arylglyoxals, and enols are two-stage processes. [35][36][37][38][39] It should be noted that, triethylamine was chosen as a base for the studied method. In addition, a mixture of HCl/AcOH is the optimal reaction medium for the second stage of the process.…”

Photoinduced 6π‐electrocyclization of 2,5‐dichlorothiophene containing benzofuranylacrylonitriles as efficient method for the generation of hydrogen chloride

“…Furthermore, as a result of UV-induced cyclization, a polycyclic product 4q is formed simultaneously with the photogeneration of a hydrogen chloride molecule (Scheme 4). Thus, taking into account the synthetic availability and diversity of 2-arylfuryl-3-acetic acids, [41][42][43][44][45][46][47][48] the proposed approach open access to a wide range of photoacid generators of this type.…”