Synthesis of Cross-Linked Ethylene Glycol Dimethacrylate and Cyclic Methacrylic Anhydride Polymer Structures by Pulsed Plasma Deposition

Abstract

New types of reaction pathways have been identified during pulsed plasma polymerization of difunctional precursor molecules. Ethylene glycol dimethacrylate is found to give rise to a highly cross-linked polymeric network, while methacrylic anhydride undergoes cyclopolymerization. The deposited films have been characterized by infrared spectroscopy and solvent swelling studies.

Loading and Release of Drugs from Oxygen‐rich Plasma Polymer Coatings

“…It is thus possible to obtain thin layers of macromolecular materials, known as “plasma polymers” (PP), to distinguish them from conventional polymers. PP have been deposited from precursors such as alcohols, carboxylic acids, acid chlorides, simple amines, anhydrides, ethylene glycols, etc., with high densities of functional groups and varying degrees of cross‐linking 11–21. An important property, the PP stability in air or liquids such as water, is affected by: (i) the inherent reactivity of its functional groups; (ii) the balance between bonding and scission processes during deposition, which determine the degree of cross‐linking and possible formation of oligomers; and (iii) the concentration of incorporated free radicals, which also contribute to cross‐linking reactions 22.…”

Recent and Expected Roles of Plasma‐Polymerized Films for Biomedical Applications

“…Precursors such as alcohols, [3,4] carboxylic acids, [5,6] acid chlorides, [7,8] simple amines, [9,10] anhydrides, [11][12][13] and ethylene glycols [14,15] have been successfully deposited with a very high functional group density and various degrees of cross-link density. The surfaces deposited are generally marked by a high reactivity, characteristic of the functional groups they contain.…”

A Substrate‐Independent Approach for the Surface Immobilization of Oligonucleotides using Aldehyde Functionalized Surfaces

“…Compared to conventional aldehyde-bearing slides based on SAMs, which are highly compact (rigid) in nature, the steric flexibility of plasma-chemical-functionalized layers is clearly an advantageous factor. [29,40] Biologists have recognized the need for flexible linker layers to improve hybridization efficiency, reporting that even linkers of <28 Å can increase hybridization fourfold, [46] whilst linkers >40 Å offer a 150-fold increase in hybridization efficiency. [47] Furthermore, in the present study, the plasmachemical-functionalized aldehyde layers give rise to good DNA-DNA recognition, as demonstrated by the high selectivity of complementary versus non-complementary hybridization.…”

“…1 and Table 1). Further confirmation of good structural retention and minimal crosslinking [40] was evident from the resolved meta-substituted phenyl ring bands which include semi-circle stretches (1446 cm À1 and 1478 cm…”