Synthesis of curcumin complexes with iron(<scp>iii</scp>) and manganese(<scp>ii</scp>), and effects of curcumin–iron(<scp>iii</scp>) on Alzheimer's disease

Biçer, Nurcan; Yıldız, Emel; Yegani, Arash Alizadeh; Aksu, Fazilet

doi:10.1039/c7nj04223j

Cited by 30 publications

(18 citation statements)

References 25 publications

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“…In another research, Paramera et al determined the stability of yeast cellloaded curcumin, it showed that yeast cells restricted the curcumin from environmental factors (i.e., light, humidity, and heat) (Paramera et al, 2011b). Curcumin prepared with Mn (II) and Fe (III) salts exhibited potent activity to Alzheimer's disease in Swiss albino male rats (Bicer et al, 2018). Palladium (II) complexes with curcumin synthesized had exhibited a strong antitumor effect to MCF-7, HeLa, and A549 tumor cells (Li et al, 2018).…”

Section: Nanospheres and Microcapsulesmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

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Section: Nanospheres and Microcapsulesmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

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“…The results showed that CRANAD‐17, a curcumin scaffold, reduced Aβ fibril formation, inhibited the aggregation of Aβ42, and prevented the β42 cross‐linking induced by Cu 2+ . Likewise, in vivo studies of the metal complex of curcumin with Fe 3+ have demonstrated a reduction in the accumulation of Aβ 25‐35 and strengthened the memory of rats compared to a curcumin‐Mn 2+ complex and curcumin alone (Fig. ).…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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“…Moreover, the side chain carboxyl group of heme may interact with one the hydroxyl groups of curcumin. 24,25…”

Section: Quantitative Methodsmentioning

confidence: 99%

Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential

Abu‐Lafi¹,

Akkawi²,

Abu-Remeleh³

et al. 2019

PPIJ

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Natural curcuminod isolates from turmeric Curcuma longa that belongs to ginger family Zingiberaceae were collected using reversed phase preparative HPLC coupled to photodiode array detector and their in-vitro effect on β-hematin inhibition were explored. Turmeric ethanolic crude extract was tenfold less active in comparison to chloroquine positive control. Moreover, semi-quantitative and quantitative analysis results revealed that curcumin analytical standard, and to a lesser extent, the turmeric three natural isolates impeded β-hematin formation in a relatively comparable extent to chloroquine and amodiaquine positive controls. This result unequivocally indicates the key role curcumin active ingredient plays as an inhibitor of β-hematin formation. Edible turmeric root powder is commercially available and safe to use.

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Synthesis of curcumin complexes with iron(iii) and manganese(ii), and effects of curcumin–iron(iii) on Alzheimer's disease

Abstract: Plants provide a wealth of bioactive compounds which aid in exerting a substantial strategy for the treatment of neurological disorders such as Alzheimer's disease and dementia.

Cited by 30 publications

References 25 publications

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Biological properties of metal complexes of curcumin

Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential

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