Synthesis of curcumin-loaded chitosan phosphate nanoparticle and study of its cytotoxicity and antimicrobial activity

Deka, Chayanika; Aidew, Lipika; Devi, Nilakshee; Buragohain, Alak Kumar; Kakati, Dilip Kumar

doi:10.1080/09205063.2016.1226051

Cited by 26 publications

(14 citation statements)

References 33 publications

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“…aureus, and from 20 mm (Cur-Cs/WPC NPs) to 28 mm (Cur-Cs/α-La NPs) for P. aeruginosa. These results are in line with those of Deka et al [49] who reported that the water solubility and antimicrobial activity of curcumin were significantly improved by curcumin nanoparticle formation compared to curcumin alone.…”

Section: Antimicrobial Activitysupporting

confidence: 92%

Improving the Functional Activities of Curcumin Using Milk Proteins as Nanocarriers

Taha

El‐Sherbiny

Enomoto

et al. 2020

Foods

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Curcumin is one of the most common spices worldwide. It has potential benefits, but its poor solubility and bioavailability have restricted its application. To overcome these problems, this study aimed to assess the efficacy of sodium caseinate (SC), α-lactalbumin (α-La), β-lactoglobulin (β-lg), whey protein concentrate (WPC) and whey protein isolate (WPI) as nanocarriers of curcumin. Furthermore, the antioxidant, anticancer and antimicrobial activities of the formed nanoparticles were examined. The physicochemical characteristics of the formed nanoparticles as well as the entrapment efficiency (%) and the in vitro behavior regarding the release of curcumin (%) were examined. The results showed that the formation of curcumin–milk protein nanoparticles enhanced both the entrapment efficiency and the in vitro behavior release of curcumin (%). Cur/β-lg nanoparticles had the highest antioxidant activity, while SC and WPC nanoparticles had the highest anticancer effect. The antimicrobial activity of the formed nanoparticles was much higher compared to curcumin and the native milk proteins.

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Section: Antimicrobial Activitysupporting

confidence: 92%

Improving the Functional Activities of Curcumin Using Milk Proteins as Nanocarriers

Taha

El‐Sherbiny

Enomoto

et al. 2020

Foods

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“…In ethanolic extracts of the plant, there are three main curcuminoids present: curcumin, desmethoxycurcumin and bisdemethoxycurcumin, curcumin being the most abundant . Studies show that curcumin has anti‐inflammatory, analgesic, antiseptic, antiparasitic, antioxidant, antineoplastic and other activities . Regarding activity on C. albicans , efficacy against standard strains and against clinical isolates was demonstrated, in addition to its ability to significantly decrease the minimum inhibitory concentration of fluconazole, acting in synergy with this drug …”

Section: Introductionmentioning

confidence: 99%

Formulation, stability study and preclinical evaluation of a vaginal cream containing curcumin in a rat model of vulvovaginal candidiasis

Fernandes

Amorim

Silva

et al. 2018

Mycoses

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Owing to the growing resistance among isolates of Candida species to usual antifungal agents and the well-known therapeutic potential of curcumin, the purpose of this study was to develop and validate a vaginal formulation containing this substance and to evaluating its effectiveness in the treatment of experimental vulvovaginal candidiasis. Curcumin was incorporated in a vaginal cream in three concentrations (0.01%, 0.1% and 1.0%). The different concentrations of the cream and its controls were intravaginally administered in an immunosuppressed rat model to evaluate the efficacy in the treatment of experimental vulvovaginal candidiasis. Samples of the cream were also subjected to centrifugation and physical stability tests and an analytical method for quantification of curcumin was validated based on HPLC. The formulation was stable and the HPLC method could be considered suitable for the quantitative determination of curcumin in the cream. After 6 days of preclinical study, the number of infected animals was 1/6 in all groups treated with curcumin vaginal cream and the fungal burden showed a progressive reduction. Reduction in the inflammatory infiltrate was observed in the group treated with 1.0% cream. Vaginal cream containing curcumin could be considered a promising effective antifungal medicine in the treatment of vulvovaginal candidiasis.

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“…The cell viability remains higher than 75% for RH concentrations lower than 25 μg/ml. The increased cytotoxicity of the prepared nanoparticles, compared to RH solution, may be attributed to the positive surface charge of the prepared nanoparticles, [ 30 ] and apoptotic and membrane rupture properties of chitosan. [ 31 ] This is in addition to the high sensitivity of macrophage cell line, which is related to their higher degree of cellular differentiation.…”

Section: Resultsmentioning

confidence: 99%

Biocompatible mucoadhesive nanoparticles for brain targeting of ropinirole hydrochloride: Formulations, radiolabeling and biodistribution

2022

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Two nanoformulations with mucoadhesive properties and brain-targeting mechanisms were designed to deliver the anti-Parkinson's drug, ropinirole hydrochloride (RH). In the first formulation, RH and the amphiphilic block copolymer methoxy poly(ethylene glycol)b-poly(caprolactone) were assembled in a core-shell morphology followed by coating with a mucoadhesive chitosan outer layer producing a multilayer vehicle (MLV). In the second formulation, RH was encapsulated during the polyelectrolyte complexation of two natural polymers, chitosan and alginate producing RH-loaded chitosan-alginate polyelectrolyte (PEC) nanocomplex. Conditions of each formulation were adopted for optimal drug loading. Physico-chemical characterization of the prepared formulations (particle size, polydispersity index and zeta-potential) exhibited stable monodispersed nanoparticles. RH was radiolabeled by I-131 radiotracer in a high-radiochemical yield.Biodistribution and brain targeting of RH from the prepared formulations were studied after administration of 131 I-RH-loaded nanoparticles to albino mice via intranasal and intravenous routs. Elevated brain radioactivity was detected post IN administration of ( 131 I-RH/PCL-PEG/CS) nanoparticles and ( 131 I-RH/CS-ALG) nanoparticles comparing with the IN administrated RH solutions (C max = 2.8 ± 0.3, 2 ± 0.3, 0.93 ± 0.03% radioactivity/g, 1 h post administration, respectively). This demonstrated that a relatively highbrain targeting could be achieved via intranasal route of administration of RH-loaded nanoparticles. The proposed models are further potential for application to deliver many other brain-targeting therapeutics.

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Synthesis of curcumin-loaded chitosan phosphate nanoparticle and study of its cytotoxicity and antimicrobial activity

Cited by 26 publications

References 33 publications

Improving the Functional Activities of Curcumin Using Milk Proteins as Nanocarriers

Improving the Functional Activities of Curcumin Using Milk Proteins as Nanocarriers

Formulation, stability study and preclinical evaluation of a vaginal cream containing curcumin in a rat model of vulvovaginal candidiasis

Biocompatible mucoadhesive nanoparticles for brain targeting of ropinirole hydrochloride: Formulations, radiolabeling and biodistribution

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