Synthesis of cyclodextrin polymers containing glutamic acid and their use for the synthesis of Ag nanoparticles

Souza, Viviane Costa de; Barros, Caio; Tasić, Ljubica; Gimenez, Iara F.; Camargo, Zaine Teixeira

doi:10.1016/j.carbpol.2018.08.101

Cited by 14 publications

(4 citation statements)

References 29 publications

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“…CDs have been widely explored in polymer chemistry because of their ability to form complexes with hydrophilic polymers, monomers and drugs. Chemically crosslinked or grafted with polymer, CDs have been proposed for use in smart drug delivery systems in many studies [10,11,14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation

2019

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The topical administration route is commonly used for targeting therapeutics to the eye; however, improving the bioavailability of drugs applied directly to the eye remains a challenge. Different strategies have been studied to address this challenge. One of them is the use of aggregates that are formed easily by self-assembly of cyclodextrin (CD)/drug complexes in aqueous solution. The aim of this study was to design a new eye drop formulation based on aggregates formed between CD/drug complexes. For this purpose, the physicochemical properties of the aggregates associated with six CDs and selected water-soluble polymers were analysed. Complex formation was studied using differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR) and 1H nuclear magnetic resonance spectroscopy (1H-NMR). Results showed that HPβCD performed best in terms of solubilization, while γCD performed best in terms of enhancing nanoaggregate formation. Formation of inclusion complexes was confirmed by DSC, FT-IR and 1H-NMR studies. A mixture of 15% (w/v) γCD and 8% (w/v) HPβCD was selected for formulation studies. It was concluded that formulations with aggregate sizes less than 1 µm and viscosity around 10–19 centipoises can be easily prepared using a mixture of CDs. Formulations containing polymeric drug/CD nanoaggregates represent an interesting strategy for enhanced topical delivery of nepafenac.

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Section: Introductionmentioning

confidence: 99%

Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation

2019

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Section: Methodsmentioning

confidence: 99%

“…MO was used as a guest molecular probe to the CD cavity in this measurement according to the decrease of the absorbance at 506 nm of dye solutions when put into contact with the SACD. 24 Briefly, 0.008 mg/mL of MO solution was prepared and adjusted to pH 2.8 using sulfuric acid. Then, 10 mL of the above solution was withdrawn and placed in flasks containing 20 mg of SACD or β-CD; after incubating in the dark with constant stirring for 3 h, the absorbance of the solution was measured at 506 nm using an UV−vis spectrophotometer (UV−1800PC, Mapada, China).…”

Section: Methodsmentioning

confidence: 99%

Simple Strategy Preparing Cyclodextrin Carboxylate as a Highly Effective Carrier for Bioactive Compounds

Qiu

McClements

et al. 2021

J. Agric. Food Chem.

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Many phytochemicals suffer from poor water dispersity and storage stability, which restrict their application within aqueous-based commercial products. β-Cyclodextrin (β-CD) is a water-dispersible molecule with a hydrophobic core that can encapsulate and protect non-polar substances. The functional attributes of β-CD can be further enhanced by chemical modification. In this study, a simple and effective dry-heating process was applied to fabricate succinic acid (SA)-modified β-CD (SACD) through esterification. SACD showed better encapsulation property than non-modified β-CD to guest molecules such as methyl orange (up to 1.41-folds of β-CD) and curcumin (with an encapsulation efficiency of up to 10 mg/g). Meanwhile, higher water solubility (up to 469.30 g per 100 g of H 2 O) was achieved for SACD, indicating that a high dose of SACD could be applied in an aqueous food matrix. Such a simple strategy exhibiting low cytotoxicity shows great potential incorporating bioactive compounds into functional foods.

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“…4nitrofenol dapat direduksi dengan NaBH4 tetapi memerlukan waktu yang cukup lama, dengan bantuan katalis reaksi ini dapat berlangsung dalam hitungan menit. Berbagai agen penstabil nanopartikel perak dilaporkan memberikan sifat katalitik dalam reduksi 4nitrofenol seperti ekstrak poria (5), PVA (6), asam glutamat (7), dan tapioka (8). Pada penelitian ini akan difokuskan pada reduksi 4-nitrofenol menjadi 4-aminofenol dengan katalis nanopartikel perak yang terkonjugasi L-lisin sebagai agen penstabil.…”

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Reduksi Katalitik 4-Nitrofenol dengan Katalis Nanopartikel Perak Terkonjugasi L-Lisine

Alfanaar

Afthoni

2021

rjna

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Nanopartikel perak berpotensi menjadi katalis homogen dalam reduksi 4-nitrofenol menjadi 4-aminofenol. Berbagai penelitian menunjukan L-lisine berpotensi bertindak sebagai agen penstabil nanopartikel perak sehingga mempengaruhi sifat katalitik nanopartikel perak. Pada penelitian ini dilakukan reduksi 4-nitrofenol menggunakan katalis nanopartikel perak yang terkonjugasi dengan L-lisini dengan reduktor NaBH4. Dari hasil reduksi didapatkan nanopartikel perak dengan dosis 50 ?L mampu mengubah 99,99% 4-nitrofenol menjadi 4-aminofenol dengan tetapan laju reaksi 0,1130 menit-1.

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Synthesis of cyclodextrin polymers containing glutamic acid and their use for the synthesis of Ag nanoparticles

Cited by 14 publications

References 29 publications

Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation

Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation

Simple Strategy Preparing Cyclodextrin Carboxylate as a Highly Effective Carrier for Bioactive Compounds

Reduksi Katalitik 4-Nitrofenol dengan Katalis Nanopartikel Perak Terkonjugasi L-Lisine

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