Synthesis of Deoxyribonucleic Acid in the Liver of Hypophysectomized Rats After Partial Hepatectomy.

Aging and the Liver: An Update

“…Liver regeneration.-Although the liver's regenerative potential appears to remain intact in aging rats, the rate of regeneration declines with increasing age (66). This conclusion is based on the observation that it takes considerably longer for partially resected livers in old animals to regain their original volume in comparison to young animals.…”

24‐hour variations in DNA of the liver in young and adult male mice

“…Circadian variations have been reported in DNA synthesis of young mouse liver (Jardetzky et al, 1956), adult mouse regenerating liver (Barnum etal., 1957;Bade et al, 1966) and adult rat regenerating liver Rabes, 1969). The Nijmegen group (Horwath, 1963;Eling, 1967;Mayersbach, 1967;Jerusalem, 1967) has reported circadian variations of DNA concentration in the liver and UV absorbance measured in nuclei of hepatic cells, in adult rats.…”

A liver specific gene that is expressed in growth hormone transgenic mice and in normal female mice as a function of age

“…GH administration to partially hepatectomized rats showed a significant increase in liver weight [47] and in DNA synthesis [48]. Meanwhile, pituitary ablated (hypophysectomized) rats that have undergone partial hepatectomy showed a delay in the restoration of liver weight [49] and in DNA synthesis [50]. Furthermore, hepatectomy of hypophysectomized rats treated with GH accelerates induction of hepatic growth factor (HGF) mRNA and DNA synthesis [51] and restores the rate of liver weight gain close to that of non-hypophysectomized animals that had undergone hepatectomy [52].…”