Synthesis of diazaadamantanes from 1,5-dimethylbispidinone and some natural ketones

Synthesis of 8-oxa-2-azaspiro[4.5]decane

“…Currently, spiro compounds are attracting attention as scaff olds in the search for modern drugs. [2][3][4][5][6][7][8][9] The combination of the intrinsic complexity and, more importantly, the rigidity of these scaff olds off er a number of advantages for programmed drug discovery.…”